Q6FQQ6

PR
Gene name
TIF1 (TIF41, CAGL0I04356g)
Protein name
ATP-dependent RNA helicase eIF4A
Names
Eukaryotic initiation factor 4A, eIF-4A, Translation initiation factor 1
Species
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
KEGG Pathway
cgr:CAGL0I04356g
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6FQQ6

Entry ID Method Resolution Chain Position Source
AF-Q6FQQ6-F1 Predicted AlphaFoldDB

No variants for Q6FQQ6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6FQQ6

No associated diseases with Q6FQQ6

6 regional properties for Q6FQQ6

Type Name Position InterPro Accession
conserved_site ATP-dependent RNA helicase DEAD-box, conserved site 169 - 177 IPR000629
domain Helicase, C-terminal 234 - 395 IPR001650
domain DEAD/DEAH box helicase domain 48 - 211 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 42 - 238 IPR014001
domain RNA helicase, DEAD-box type, Q motif 23 - 51 IPR014014
domain ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain 25 - 224 IPR044728

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
fungal biofilm matrix An extracellular matrix lying external to fungal cells. The fungal biofilm matrix consists of polysaccharides, proteins, lipids, and nucleic acids. Fungal biofilms mediate adherence to host tissues, and provide protection from host immune defenses.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSTDQMTQLD ESQIETNYDK VVYEFDDMNL NEKLLRGVFG YGFNKPSAIQ QRAIMPIIEG
70 80 90 100 110 120
NDVLAQAQSG TGKTGTFSIA ALQRIDPAIK APQALMLAPT RELALQIQKV VMALGFHMDI
130 140 150 160 170 180
KVHACIGGTS FVEDAEGLRD AQIVVGTPGR VFDNIQRRKF KVDNIKMFIL DEADEMLSTG
190 200 210 220 230 240
FKEQIYQIFT MLPPTTQVVL LSATMPRDVL EVTAKFMQNP VRILVKKDEL TLEGIKQFYV
250 260 270 280 290 300
NVEEEQFKYD CLTDLYDSIS VTQAVIFCNT RRKVEELTQR LTADNFTVSS IYSDLPQQER
310 320 330 340 350 360
DTIMKEFRSG SSRILISTDL LARGIDVQQV SLVINYDLPT NKENYIHRIG RGGRFGRKGV
370 380 390
AINFIVNEDV QALRELEQFY STQIEELPSD IGTLFT