Q6FPK7

PR
Gene name
ICL1
Protein name
Isocitrate lyase
Names
ICL, Isocitrase, Isocitratase, Methylisocitrate lyase, MICA, Threo-D(S)-isocitrate glyoxylate-lyase
Species
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
KEGG Pathway
cgr:CAGL0J03058g
EC number
4.1.3.1: Oxo-acid-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-44 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6FPK7

Entry ID Method Resolution Chain Position Source
AF-Q6FPK7-F1 Predicted AlphaFoldDB

No variants for Q6FPK7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6FPK7

No associated diseases with Q6FPK7

2 regional properties for Q6FPK7

Type Name Position InterPro Accession
conserved_site Isocitrate lyase/phosphorylmutase, conserved site 214 - 219 IPR018523
domain ICL/PEPM domain 75 - 487 IPR039556

Functions

Description
EC Number 4.1.3.1 Oxo-acid-lyases
Subcellular Localization
  • Glyoxysome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
glyoxysome A specialized form of peroxisome that contains the enzymes of the glyoxylate pathway. The glyoxysome is found in some plant cells, notably the cells of germinating seeds.

3 GO annotations of molecular function

Name Definition
isocitrate lyase activity Catalysis of the reaction: isocitrate = glyoxylate + succinate.
metal ion binding Binding to a metal ion.
methylisocitrate lyase activity Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate.

2 GO annotations of biological process

Name Definition
glyoxylate cycle A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate.
tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPVPNSEANE FQALQARIDA DAKEIEQWWS EPRWNKTKRT YSAREIAIRR GTFPPLTYPS
70 80 90 100 110 120
SVMAKKVYKV LEKHHKEGTV SRTFGALDPV QVSQMAKFLD TIYVSGWQCS STASTSNEPG
130 140 150 160 170 180
PDLADYPMDT VPNKVEHLFK AQQFHDRKQW ENRAKATSQE ELDAMGPAID YMTPIIADAD
190 200 210 220 230 240
AGHGGLTAVF KLTKMFIERG AAGIHMEDQT STNKKCGHMA GRCVIPVQEH INRLVTIRMC
250 260 270 280 290 300
ADIMHSELVI VARTDSEAAT LISSTIDTRD HYFVVGATNP DIEPFAEYMD RAIMAGVSGD
310 320 330 340 350 360
ELQKLEAAWI EKAGLKLFHE AFADEVNKSS VSNKQEIIKK FNDKVGPLTE TSHREAKKLA
370 380 390 400 410 420
KELLGKDIFF DWDLPRVREG LYRYRGGTQC SVMRARAFAP YADLVWMESN YPDFEQAREF
430 440 450 460 470 480
AEGVKAKYPD QWLAYNLSPS FNWPKAMSVD EQATFIERLG QLGYIWQFIT LAGLHTTALA
490 500 510 520 530 540
IHKFSEDFAR EGMKAYAQNV QQIEMDEGVD VLKHQKWSGA EYIDGLLKLA QGGVSATAAM
550
GQGVTEDQFK SNL