Q6FPI6

PR
Gene name
ATG15 (CAGL0J03542g)
Protein name
Putative lipase ATG15
Names
Autophagy-related protein 15
Species
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
KEGG Pathway
cgr:CAGL0J03542g
EC number
3.1.1.3: Carboxylic ester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-68 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6FPI6

Entry ID Method Resolution Chain Position Source
AF-Q6FPI6-F1 Predicted AlphaFoldDB

No variants for Q6FPI6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6FPI6

No associated diseases with Q6FPI6

1 regional properties for Q6FPI6

Type Name Position InterPro Accession
domain Fungal lipase-like domain 266 - 323 IPR002921

Functions

Description
EC Number 3.1.1.3 Carboxylic ester hydrolases
Subcellular Localization
  • Endosome, multivesicular body membrane ; Single-pass type II membrane protein
  • Prevacuolar compartment membrane ; Single-pass type II membrane protein
  • From ER, targeted to vacuolar lumen at the MVB vesicles via the Golgi and the prevacuolar compartment (PVC)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
multivesicular body membrane The lipid bilayer surrounding a multivesicular body.
vacuolar lumen The volume enclosed within the vacuolar membrane.

2 GO annotations of molecular function

Name Definition
phospholipase activity Catalysis of the hydrolysis of a glycerophospholipid.
triglyceride lipase activity Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.

6 GO annotations of biological process

Name Definition
multivesicular body membrane disassembly The controlled breakdown of the membranes of multivesicular bodies.
neutral lipid catabolic process The chemical reactions and pathways resulting in the breakdown of neutral lipids, lipids only soluble in solvents of very low polarity.
pexophagy The selective autophagy process in which a peroxisome is degraded by macroautophagy.
phosphatidylserine catabolic process The chemical reactions and pathways resulting in the breakdown of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine.
piecemeal microautophagy of the nucleus Degradation of a cell nucleus by lysosomal microautophagy.
vacuolar protein processing Protein processing that takes place in the vacuole. Most protein processing in the vacuole represents proteolytic cleavage of precursors to form active enzymes.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLGRQVTMLL KVIVAVAVLF VWHRSRDSSR GDGSNGDGLS DSSGNGFRLE HIWAYDPEDV
70 80 90 100 110 120
VSSCVDVSEE MRVSADEYVS MESGSEFVES WWAKTGARPF SHVFDLRSRS MDIQRLQDRD
130 140 150 160 170 180
PVSMEKYIDF SLENPELART IELEWETAKI QVPDVRNRNT VLALALMSSN AYVRTPYTGD
190 200 210 220 230 240
WRNLSSSWGH TGEEKFGWDK DGLRGHIFVN KITKVVVIAI KGTSSQGLFG SGEEDTITND
250 260 270 280 290 300
KINDNLLFSC CCARISYLWT TVCDCYMKSY TCDENCVEAE LKRKDRYYAA TLKLYKQVTE
310 320 330 340 350 360
MYPDSAIWLT GHSLGGALAA LLGRTYGVPA VTFEAPGELL PAKRLHLPLP PGLPDYEEAI
370 380 390 400 410 420
WHFGHNADPI FMGTCNGASS SCSIGGYAME TACHSGQYCM YDVVNDKGWR VNLLNHRIHR
430 440 450 460 470 480
VIDEVILEYG RPAKCQRAPT CIDCYNWKFV NKRRNRREES SSSIASSSQL TSSHSESETL
490 500
TSTDAPEKTC IGRNWLGICT DYGV