Q6FP52

PR
Gene name
SEC65 (CAGL0J06578g)
Protein name
Signal recognition particle SEC65 subunit
Names
Species
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
KEGG Pathway
cgr:CAGL0J06578g
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-144 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6FP52

Entry ID Method Resolution Chain Position Source
AF-Q6FP52-F1 Predicted AlphaFoldDB

No variants for Q6FP52

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6FP52

No associated diseases with Q6FP52

No regional properties for Q6FP52

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q6FP52

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
signal recognition particle, endoplasmic reticulum targeting A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana.

1 GO annotations of molecular function

Name Definition
7S RNA binding Binding to a 7S RNA, the RNA component of the signal recognition particle (SRP).

1 GO annotations of biological process

Name Definition
SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition The process in which SRP binds to the signal peptide in a nascent protein, causing protein elongation to pause, during cotranslational membrane targeting.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPKLEEIEDY DDIDNMDMDL AELDPTLNTP IAPKITPTVV RSQDIEEEER KKQYAGSNKE
70 80 90 100 110 120
MISFINPQTG KVEESAPITK QELDEVKKFQ VLYPCYFDKN RSHKEGRRVP IEMAVENPLA
130 140 150 160 170 180
KTISDAVREY GLLSIFEGDK CHPQDFGNPG RIRVLLKEEG KLVPSASKFS GGKRQLMKLV
190 200 210 220 230 240
AEYLQKHPTT VESLRELPYG PDFDNIEFKK IPKVKGFKMN DIVPLHSPYL WGHPMTKSIY
250 260
EAPKIEAPEK QFKAPKNKFK VVRR