Q6FNV5
Gene name |
HRD3 (CAGL0J08756g) |
Protein name |
ERAD-associated E3 ubiquitin-protein ligase component HRD3 |
Names |
|
Species |
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) |
KEGG Pathway |
cgr:CAGL0J08756g |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6FNV5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6FNV5-F1 | Predicted | AlphaFoldDB |
No variants for Q6FNV5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6FNV5 | |||||
No associated diseases with Q6FNV5
7 regional properties for Q6FNV5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Sel1-like repeat | 107 - 143 | IPR006597-1 |
| repeat | Sel1-like repeat | 147 - 184 | IPR006597-2 |
| repeat | Sel1-like repeat | 185 - 220 | IPR006597-3 |
| repeat | Sel1-like repeat | 372 - 396 | IPR006597-4 |
| repeat | Sel1-like repeat | 577 - 591 | IPR006597-5 |
| repeat | Sel1-like repeat | 592 - 623 | IPR006597-6 |
| repeat | Sel1-like repeat | 624 - 659 | IPR006597-7 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| Hrd1p ubiquitin ligase ERAD-L complex | A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p. |
| Hrd1p ubiquitin ligase ERAD-M complex | A multiprotein complex that recognizes and ubiquitinates proteins with misfolded membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| luminal surveillance complex | A multiprotein complex that recognizes ERAD-luminal misfolded substrates and brings them to the ubiquitination/extraction machinery. In yeast, this complex consists of Yos9p, Kar2p and Hrd3p proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| ubiquitin-protein transferase activity | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of protein autoubiquitination | Any process that stops, prevents or reduces the frequency, rate or extent of protein autoubiquitination. |
| retrograde protein transport, ER to cytosol | The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon. |
| ubiquitin-dependent ERAD pathway | The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLLSTYLNWA | SVLLTIAGAE | SNIDPWDEVS | SFLQGKLRKL | DVTNPNAYDM | NDNEQDATFY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VSMDYHEEEE | RSEYESVWQY | YNENSDQDWH | KSVYDKLQVS | ADQFNNTEAM | YKLSQINLWG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QYGYPHNKSV | AFQYLQKFND | MTSYENSSAL | FDLAVAYSTG | LFGTLPVDVA | RGLLYFQRSA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RLGDLKAKQV | LAYRYFSGYS | VARDVDKALL | LYKEIAEEIK | KKYSEEQWNM | VFPYIESYIV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RIPDFDEGLL | GKGLSTVPQS | VRRKKTTRPP | FAGSSNLKPI | GDVGYGEVVM | QFKFNAGNGN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PGSFVISDSE | HEDRLVELFY | TAWDLYKGTY | TRGRDCDKAK | RLLLQVYKTY | DAEVKYMDNL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QKFFYVKSLD | LLAHMYFTGE | GFERPNVQAA | LDLFDRSEKI | LEGAEISRTA | SEVDKGLISQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YYFNNTLGAL | KHYKKAKESG | NAHGILFYQL | GKLSEKNPEL | KIGDPYLYMQ | EASSQQYLPA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QYEFAKMVES | NELRKYSVED | ITRLYKAFVE | ENENIMAPHL | RLGFSELLGG | SSEVSLYAYA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| QAAEQGYEAA | QISAAYLLYQ | LPYKFDDPPE | TTIERKTMAI | SYYTRAFKQG | NTDAAVVAGD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| IYFQMKNYTK | ALSLYQSAAL | KFSAQALWNI | GYMYEHGLGV | EKDFHLAKRF | YDQILEHNQK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LYFAVKASVM | KLQLKSWFMW | LNGKELDNIS | IDQEQESTVV | RPFFDRLVQL | LKNLSRETRG |
| 730 | 740 | 750 | 760 | 770 | 780 |
| DNKKKNQHRI | LKEKKTPSQG | IMERFGLQTE | DLLTMVCVLI | IFAISMFFRT | VAPRGQWNVR |
| 790 | 800 | 810 | 820 | 830 | |
| INGVNIAGGN | ALGEEGNPEN | ENEEDDENDD | EGRARARNNF | GFGNNFDVQV | FAI |