Q6FMI5
Gene name |
LYS2 (CAGL0K07788g) |
Protein name |
L-2-aminoadipate reductase large subunit |
Names |
Alpha-aminoadipate reductase, Alpha-AR, L-aminoadipate-semialdehyde dehydrogenase |
Species |
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) |
KEGG Pathway |
cgr:CAGL0K07788g |
EC number |
1.2.1.31: With NAD(+) or NADP(+) as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6FMI5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6FMI5-F1 | Predicted | AlphaFoldDB |
No variants for Q6FMI5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6FMI5 | |||||
No associated diseases with Q6FMI5
8 regional properties for Q6FMI5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | AMP-dependent synthetase/ligase domain | 228 - 691 | IPR000873 |
| ptm | Phosphopantetheine attachment site | 860 - 875 | IPR006162 |
| domain | Phosphopantetheine binding ACP domain | 828 - 905 | IPR009081 |
| domain | Amino acid adenylation domain | 256 - 714 | IPR010071 |
| domain | Thioester reductase-like domain | 955 - 1338 | IPR010080 |
| domain | Fatty acyl-coenzyme A reductase, NAD-binding domain | 958 - 1208 | IPR013120 |
| domain | Polyketide synthase, phosphopantetheine-binding domain | 834 - 905 | IPR020806 |
| conserved_site | AMP-binding, conserved site | 404 - 415 | IPR020845 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.2.1.31 | With NAD(+) or NADP(+) as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| L-aminoadipate-semialdehyde dehydrogenase activity | Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+. |
| phosphopantetheine binding | Binding to phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| lysine biosynthetic process via aminoadipic acid | The chemical reactions and pathways resulting in the formation of lysine by the aminoadipic pathway. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSWKERLDNP | TLSVWPHDYL | RPHAEPFVEQ | GTYSISIPQL | SGDYATLLAA | WTALLYRVTG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DDDIVLYVRD | NKVLRFTITP | ELTFTQLQNK | INEQLAELAN | VEGTNFDALS | ESLQKESGLE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RPPQLFRIAC | VTEDLQLDRY | THSPLDIGLQ | LHESSSDVSI | VFNKLLFSQD | RITILADQLT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LFLTSVLQNA | KQVFTKVSLI | TDSSTSILPD | PKANLDWCGF | VGCIHDIFQD | NAEKFPERTC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VVETPPINST | KTRTFTYKDI | NEASNIVAHY | LINTGIKRGD | VVMIYSSRGV | DLMVCVMGVL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KAGATFSVID | PAYPPARQTI | YLGVAKPKGL | IVIRAAGQLD | QLVEDYITKE | LDLVSRIPSI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AIQDNGTVEG | GSLPSESGDV | LASYTELKST | RTGVVVGPDS | NPTLSFTSGS | EGIPKGVLGR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HFSLAYYFSW | MAKQFNLSEN | DKFTMLSGIA | HDPIQRDMFT | PLFLGAQLYV | PTQDDIGTPG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RLAEWMGKYG | CTVTHLTPAM | GQLLTAQAVT | PFPKLHHAFF | VGDILTKRDC | LRLQTLAENC |
| 550 | 560 | 570 | 580 | 590 | 600 |
| CIVNMYGTTE | TQRAVSYFEV | TSRSQDPHFL | KKLKDVMPAG | RGMKNVQLLV | VNRNDRTQVC |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GVGEIGEIYV | RAGGLAEGYR | GLPDLNKEKF | VNNWFVEEGH | WNYLDKDLEA | PWKEFWQGPR |
| 670 | 680 | 690 | 700 | 710 | 720 |
| DRLYRTGDLG | RYLPNGDCEC | CGRADDQVKI | RGFRIELGEI | DTNISQHPLV | RENITLVRNN |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LEGEKCLVTY | MVPRFDKPEL | ENFKIEVPSN | ISDDPVVCGL | IGYSPFTKDL | KAFLKKRLAS |
| 790 | 800 | 810 | 820 | 830 | 840 |
| YAIPSLIIVL | PKLPLNPNGK | VDKPKLQFPT | VKQLELVAKN | SSIDINDSEF | NQQEREIRDL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| WLECLPTKPT | SISPEDSFFD | LGGHSILATK | MIFTVKKQLN | VELPLGTIFK | YPTIKAFAAE |
| 910 | 920 | 930 | 940 | 950 | 960 |
| VSRLKSTDKI | EEETTALTAD | YASDAASLID | TLPKSYPAAR | ALGSPSEMAG | PTTVNIFVTG |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| VTGFLGSFIL | SDILNRTVTG | VNFKIFAHVR | AADETSGLDR | IRKAGTVYGT | WKEEYANSLQ |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| VVIGDLSKKN | FGLTDDKWSH | LSETIDIIIH | NGALVHWVYP | YSKLRNANVV | STINIMNLAS |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| EGKPKLFNFV | SSTSVLDTNH | YFELSDKLQQ | SGKEGIPESD | DLMGSSLGLT | SGYGQSKWAA |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| EHIIRAAGKR | GLRGSIIRPG | YVTGASYNGS | SNTDDFLLRF | LKSAVQLGKI | PDINNTVNMV |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| PVDQVARVVV | AASINPPCGD | DLCVVHVNAH | PRIIFKDYLY | ELKNYGYDVE | IENYEQWKKT |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| LEEAVIERSE | DNALFPLLHM | VLGDLEDSTK | APELDDKNAI | TSLRADIEWT | NEDRTKGMGA |
| 1330 | 1340 | 1350 | 1360 | 1370 | |
| TPEQIGIYIS | FLESVGFLPH | PKHFGDKALP | NIKISEQQKE | LVASGAGARS | SSAA |