Q6FLA4

PR
Gene name
ERB1
Protein name
Ribosome biogenesis protein ERB1
Names
Eukaryotic ribosome biogenesis protein 1
Species
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
KEGG Pathway
cgr:CAGL0L04950g
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-448 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6FLA4

Entry ID Method Resolution Chain Position Source
AF-Q6FLA4-F1 Predicted AlphaFoldDB

No variants for Q6FLA4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6FLA4

No associated diseases with Q6FLA4

8 regional properties for Q6FLA4

Type Name Position InterPro Accession
repeat WD40 repeat 425 - 473 IPR001680-1
repeat WD40 repeat 473 - 513 IPR001680-2
repeat WD40 repeat 617 - 664 IPR001680-3
repeat WD40 repeat 667 - 706 IPR001680-4
repeat WD40 repeat 710 - 749 IPR001680-5
repeat WD40 repeat 761 - 805 IPR001680-6
domain BOP1, N-terminal domain 164 - 425 IPR012953
conserved_site WD40 repeat, conserved site 451 - 465 IPR019775

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
  • Nucleus, nucleoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
PeBoW complex A protein complex that is involved in coordinating ribosome biogenesis with cell cycle progression. In human, it is composed of Pes1, Bop1, and WDR12; in Saccharomyces the proteins are known as Nop7p, Erb1 and Ytm1 respectively.
preribosome, large subunit precursor A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit.

2 GO annotations of molecular function

Name Definition
large ribosomal subunit rRNA binding Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA.
ribonucleoprotein complex binding Binding to a complex of RNA and protein.

2 GO annotations of biological process

Name Definition
maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVKGRKSQKA DKVTKAKKRV ADEVDESESE PELQVEGLID AEAESEDDES FESAEENASA
70 80 90 100 110 120
EEDEEDEEDE EDSDAELNKL LAEEEGDDSE SEYNTSDFSE DDTKSMTDKL SGVKLTTIAE
130 140 150 160 170 180
PIIKTKFSDG TPRVIKPEIN PVYDSDDSDI ESKNTIGNIP LSVYDEMPHI GYDVNGKRIM
190 200 210 220 230 240
RPARASALDQ LLDTIELPEG WTGLLDKESG ASLNISKEEL ELISKIQRNE QTDESTNPYE
250 260 270 280 290 300
PLIDWFTRHE EVMPLSAAPE PKRRFVPSKN EAKRIMKIVK AIREGRIIPP KKMKELREKE
310 320 330 340 350 360
KSEDFNYDLW GDSTETNDHI MNLRAPKLPP PTNEESYNPP AEYLPTEEEI KEWENTEYSE
370 380 390 400 410 420
RERNFVPKKY DSLRKVPGYT ESVRERFERS LDLYLAPRMR KNKLNIDPES LIPELPSPKD
430 440 450 460 470 480
LRPFPIRCST IYSGHEGKIR TLSIDPTGIW LATGSDDGSV RIWEILTGRE VYRVQLVNKE
490 500 510 520 530 540
DNPEDNIHSV EWNPDGSVGI LAVAVGNNIF LIVPPIFGYD IENAGKVRIE HGFGYDTFGS
550 560 570 580 590 600
TKKANLEVNG SDLESDDEAA NANTAVKKQV AQWHKPTQRQ MEQDICIVIV CKKPVKKLSW
610 620 630 640 650 660
HRKGDYFVTV QPDSGNTSVL IHQLSKHLTQ SPFRKSKGII MDAKFHPFKP QLFVCSQRYV
670 680 690 700 710 720
RIYDLSQQVL VKKLLPGARW LSNIDIHPRG DNLIASSYDK RVLWHDLDLA ATPYKTLRYH
730 740 750 760 770 780
DKAVRSTTFH KKLPLFCSAA DDGFIHIFHA TVYDDMMKNP MIVPLKKLTG HKVQGHLGVL
790 800
DTIWHPKEAW LFSAGADNTA RMWTT