Q6FJA3

PR
Gene name
PDC1 (PDC, CAGL0M07920g)
Protein name
Pyruvate decarboxylase
Names
Species
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
KEGG Pathway
cgr:CAGL0M07920g
EC number
4.1.1.1: Carboxy-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

223-297 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6FJA3

Entry ID Method Resolution Chain Position Source
AF-Q6FJA3-F1 Predicted AlphaFoldDB

No variants for Q6FJA3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6FJA3

No associated diseases with Q6FJA3

6 regional properties for Q6FJA3

Type Name Position InterPro Accession
conserved_site TPP-binding enzyme, conserved site 427 - 446 IPR000399
domain Thiamine pyrophosphate enzyme, TPP-binding 401 - 513 IPR011766
domain Thiamine pyrophosphate enzyme, central domain 201 - 327 IPR012000
domain Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain 5 - 178 IPR012001
domain Pyruvate decarboxylase/indolepyruvate decarboxylase-like, pyrimidine-binding domain 8 - 169 IPR047213
domain Pyruvate decarboxylase/indolepyruvate decarboxylase-like, PP-binding domain 364 - 549 IPR047214

Functions

Description
EC Number 4.1.1.1 Carboxy-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cell surface The external part of the cell wall and/or plasma membrane.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
fungal biofilm matrix An extracellular matrix lying external to fungal cells. The fungal biofilm matrix consists of polysaccharides, proteins, lipids, and nucleic acids. Fungal biofilms mediate adherence to host tissues, and provide protection from host immune defenses.

3 GO annotations of molecular function

Name Definition
magnesium ion binding Binding to a magnesium (Mg) ion.
pyruvate decarboxylase activity Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2.
thiamine pyrophosphate binding Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases.

1 GO annotations of biological process

Name Definition
pyruvate metabolic process The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSEITLGRYL FERLNQVDVK TIFGLPGDFN LSLLDKIYEV EGMRWAGNAN ELNAAYAADG
70 80 90 100 110 120
YARIKGMSCI ITTFGVGELS ALNGIAGSYA EHVGVLHVVG VPSISSQAKQ LLLHHTLGNG
130 140 150 160 170 180
DFTVFHRMSA NISETTAMVT DIATAPAEID RCIRTTYITQ RPVYLGLPAN LVDLKVPAKL
190 200 210 220 230 240
LETPIDLSLK PNDPEAETEV VDTVLELIKA AKNPVILADA CASRHDVKAE TKKLIDATQF
250 260 270 280 290 300
PSFVTPMGKG SIDEQHPRFG GVYVGTLSRP EVKEAVESAD LILSVGALLS DFNTGSFSYS
310 320 330 340 350 360
YKTKNIVEFH SDYIKIRNAT FPGVQMKFAL QKLLNAVPEA IKGYKPVPVP ARVPENKSCD
370 380 390 400 410 420
PATPLKQEWM WNQVSKFLQE GDVVITETGT SAFGINQTPF PNNAYGISQV LWGSIGFTTG
430 440 450 460 470 480
ACLGAAFAAE EIDPKKRVIL FIGDGSLQLT VQEISTMIRW GLKPYLFVLN NDGYTIERLI
490 500 510 520 530 540
HGEKAGYNDI QNWDHLALLP TFGAKDYENH RVATTGEWDK LTQDKEFNKN SKIRMIEVML
550 560
PVMDAPTSLI EQAKLTASIN AKQE