Q6FIR8
Gene name |
GEM1 (CAGL0M12276g) |
Protein name |
Mitochondrial Rho GTPase 1 |
Names |
GTPase EF-hand protein of mitochondria 1 |
Species |
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) |
KEGG Pathway |
cgr:CAGL0M12276g |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6FIR8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6FIR8-F1 | Predicted | AlphaFoldDB |
No variants for Q6FIR8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6FIR8 | |||||
No associated diseases with Q6FIR8
8 regional properties for Q6FIR8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | EF-hand domain | 196 - 224 | IPR002048-1 |
| domain | EF-hand domain | 320 - 355 | IPR002048-2 |
| domain | Mitochondrial Rho GTPase 1/3, EF hand associated, type-1 | 359 - 426 | IPR013566 |
| domain | EF hand associated, type-2 | 232 - 321 | IPR013567 |
| binding_site | EF-Hand 1, calcium-binding site | 205 - 217 | IPR018247-1 |
| binding_site | EF-Hand 1, calcium-binding site | 333 - 345 | IPR018247-2 |
| domain | MIRO domain | 3 - 176 | IPR020860-1 |
| domain | MIRO domain | 436 - 601 | IPR020860-2 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| ERMES complex | A protein complex that links the endoplasmic reticulum with mitochondria and may have a role in promoting exchange of calcium and phospholipids between the two organelles. |
| integral component of mitochondrial outer membrane | The component of the mitochondrial outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| heme transport | The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| mitochondrion inheritance | The distribution of mitochondria, including the mitochondrial genome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton. |
| mitochondrion-endoplasmic reticulum membrane tethering | The attachment of a mitochondrion and an endoplasmic reticulum via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles. |
| phospholipid homeostasis | Any process involved in the maintenance of an internal steady state of phospholipid within an organism or cell. |
| regulation of mitochondrion organization | Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion. |
| small GTPase mediated signal transduction | The series of molecular signals in which a small monomeric GTPase relays a signal. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTKETIRVVI | CGDDGVGKTS | LIVSLVKGQF | IPNLQAVLPP | VTIPRDFSSS | PYSPKNTVLI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DTDNSDPLAI | QRELKNADVI | WLVYSDKDSY | ERISLYWMIT | FRSLGLNIPV | ILCKNKCDQY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TTNSPLEDFL | DTKIEDEEFI | PILMAFKEVD | TCVKASAKTH | FDVNQSFYLC | QRSISYPISP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LFDAKVGDLK | PSAVAALSRI | FFLSDEDQDG | FLNDNEIMDL | QRKCFGKSID | LNELNFIKHT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LSDLTSSEEY | PSEILYCQGK | GLTKQGFIAL | NKIYTEKGRH | ETTWGILRAF | NYTDSLSIDD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AVLFPKVNVP | EQASVELSSK | GYRFLVDIFI | KFDSDNDGAL | NDTELHTLFR | STPGLPNLWL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ETNFPASTVV | NAKGFVTLQG | WLAQWTMTTY | LDYKITTAYL | VYLGFQEDAK | LAVQITKSRR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| MRRRQGRLYR | SYVTDRKVFN | CFVVGKRNSG | KSSLLESFLG | RLFSEAYSPT | IRPRVAVNNV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EVTGDKQYYL | ILQEFGEQEE | AILQNPSRLA | ECDVLCLTYD | SSDPESFSYL | LELLTNNEIM |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KDIPVVFVAL | KADLDKQQQR | CKFQPDEFTD | TLYLDHPLHV | SSTWSSSLNQ | LFKKIIQASL |
| 610 | 620 | 630 | 640 | ||
| EPGKFTPGFP | PDIKPTNIDY | SSAVILGSSI | GFLALFSYTM | IKLLKPTQQ |