Q6F494

PR
Gene name
pckG (pck, TK1405)
Protein name
Phosphoenolpyruvate carboxykinase [GTP]
Names
PEP carboxykinase, PEPCK, GTP-dependent phosphoenolpyruvate carboxykinase, GTP-PEPCK, PckTk
Species
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
KEGG Pathway
tko:TK1405
EC number
4.1.1.32: Carboxy-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

330-410 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6F494

Entry ID Method Resolution Chain Position Source
AF-Q6F494-F1 Predicted AlphaFoldDB

No variants for Q6F494

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6F494

No associated diseases with Q6F494

3 regional properties for Q6F494

Type Name Position InterPro Accession
conserved_site Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site 268 - 276 IPR018091
domain Phosphoenolpyruvate carboxykinase, C-terminal P-loop domain 244 - 603 IPR035077
domain Phosphoenolpyruvate carboxykinase, GTP-utilising, N-terminal 29 - 239 IPR035078

Functions

Description
EC Number 4.1.1.32 Carboxy-lyases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
manganese ion binding Binding to a manganese ion (Mn).
phosphoenolpyruvate carboxykinase (GTP) activity Catalysis of the reaction: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.

6 GO annotations of biological process

Name Definition
cellular response to glucose stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
gluconeogenesis The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
glycerol biosynthetic process from pyruvate The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, from other compounds, including pyruvate.
propionate catabolic process The chemical reactions and pathways resulting in the breakdown of propionate, the anion derived from propionic acid.
response to lipid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus.
response to starvation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNALERLEKL LDKEQFEKVK AIDNPELHEF LAEWIEWLEP DKVFVCTDSP EDEGYVRWKA
70 80 90 100 110 120
LYYGEERMLE TPNHTVHYDN YYDQARDKAN TAILLPGGKK LPYINTKDRD EGLKEIRELM
130 140 150 160 170 180
KGIMKGKELF VCFFVLGPKN SIFTIPAVQL TDSAYVAHSE FILYRKGYEE FKRLGRSARF
190 200 210 220 230 240
FRFVHSAGEL DERKTSKNLD KRRIYIDLED ETVYSVNTQY GGNTIGLKKL AFRLTIKRAV
250 260 270 280 290 300
EEGWLSEHMF LMRVNGPHGR KTYFTGAYPS MCGKTSTAMI PWENIVGDDL TFILPVNGIA
310 320 330 340 350 360
RGANVEKGVF GIIQGVNPED DPIIWQVLHS PVEIIFSNVL VKDGKPYWND MGIEIPDEGE
370 380 390 400 410 420
NHSGKWWRGK KDAEGNEIPP SHKNARFTVS LEHFPNVDME ALENPCGVEV GGMIFGGRDA
430 440 450 460 470 480
DTWPPVREAF NWEHGVITMG ASLESETTAA TLGKEGVRAF NPMAILDFMS VHLGDYLRNY
490 500 510 520 530 540
LEFGRKLKKT PKIFAVNYFL RENGVWLNHK LDKAVWLKWM ELRVHGDVEA IETPIGYIPK
550 560 570 580 590 600
YKDLAKLFKD VLNKEYTKED YERQFKIRVP ELLAKIDRIE EIYRKLDNVP EELFKVLEEE
610 620
RQRLLEAREK YGDYISPFAL EGE