Q6DJM7
Gene name |
cdk14 (pftk1) |
Protein name |
Cyclin-dependent kinase 14 |
Names |
Cell division protein kinase 14 |
Species |
Xenopus laevis (African clawed frog) |
KEGG Pathway |
|
EC number |
2.7.11.22: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6DJM7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6DJM7-F1 | Predicted | AlphaFoldDB |
No variants for Q6DJM7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6DJM7 | |||||
No associated diseases with Q6DJM7
No regional properties for Q6DJM7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q6DJM7 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.22 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasmic cyclin-dependent protein kinase holoenzyme complex | Cyclin-dependent protein kinase (CDK) complex found in the cytoplasm. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| cyclin-dependent protein serine/threonine kinase activity | Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| G2/M transition of mitotic cell cycle | The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of canonical Wnt signaling pathway | Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. |
| Wnt signaling pathway | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MCDMIESQPA | QKIGKMKKLR | RTLSDSFSRI | ALKKDENAID | EICVTKMSTR | NCQGIDSVIK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HLDPIPEDKK | VRVQRTQSSF | DPFEKTSNQP | TSPKFGKADS | YEKLEKLGEG | SYATVFKGKS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KVNGKLVALK | VIRLQEEEGT | PFTAIREASL | LKGLKHANIV | LLHDIIHTKE | TLTLVFEYVH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TDLCQYMDKH | PGGLNPENVK | LFLFQLLRGL | SYIHQGHILH | RDLKPQNLLI | SDTGELKLAD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FGLARAKSVP | SHTYSNEVVT | LWYRPPDVLL | GSTDYSTCLD | MWGVGCIFVE | MIQGVAAFPG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MKDIQDQLER | IFLILGTPIE | ETWPAVHSLP | HFEPERFTLY | GPKNLRQAWN | KLSYVNHAED |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LASKLLQCFP | KNRLSAQAAL | NHDYFSDLPP | RLWELSDMSS | IFTVPNVKLQ | PEAGESMRVF |
| 430 | |||||
| GKNNSFSKSL | SNSKH |