Q6DFV1
PR
Gene name |
Ncapg2 (Luzp5, Mtb) |
Protein name |
Condensin-2 complex subunit G2 |
Names |
Chromosome-associated protein G2, CAP-G2, Leucine zipper protein 5, More than blood protein, Non-SMC condensin II complex subunit G2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:76044 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6DFV1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6DFV1-F1 | Predicted | AlphaFoldDB |
67 variants for Q6DFV1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389276338 | 29 | S>Y | No | EVA | |
| rs3389258889 | 198 | Y>* | No | EVA | |
| rs3389233389 | 202 | E>D | No | EVA | |
| rs3389264439 | 213 | C>Y | No | EVA | |
| rs3389197479 | 242 | M>I | No | EVA | |
| rs3389268102 | 242 | M>L | No | EVA | |
| rs3389233328 | 261 | H>D | No | EVA | |
| rs3389197457 | 334 | L>P | No | EVA | |
| rs3389264330 | 335 | W>L | No | EVA | |
| rs3389276378 | 339 | K>N | No | EVA | |
| rs3403926321 | 350 | A>S | No | EVA | |
| rs3402417374 | 355 | E>A | No | EVA | |
| rs3389268045 | 356 | A>T | No | EVA | |
| rs223416428 | 365 | T>I | No | EVA | |
| rs246944083 | 371 | N>I | No | EVA | |
| rs246944083 | 371 | N>S | No | EVA | |
| rs3389268113 | 373 | I>F | No | EVA | |
| rs3389276403 | 478 | F>Y | No | EVA | |
| rs3412481478 | 506 | L>M | No | EVA | |
| rs3389265472 | 521 | I>M | No | EVA | |
| rs3389224967 | 522 | F>S | No | EVA | |
| rs3389251011 | 537 | E>D | No | EVA | |
| rs3389197421 | 552 | R>W | No | EVA | |
| rs3389239342 | 553 | F>L | No | EVA | |
| rs3403122274 | 559 | E>G | No | EVA | |
| rs3389264341 | 561 | T>N | No | EVA | |
| rs3411652457 | 564 | T>I | No | EVA | |
| rs3389233393 | 580 | C>* | No | EVA | |
| rs3389233358 | 581 | I>F | No | EVA | |
| rs3389239310 | 584 | T>I | No | EVA | |
| rs50218319 | 587 | E>D | No | EVA | |
| rs3403075223 | 589 | S>* | No | EVA | |
| rs1134341187 | 589 | S>* | No | EVA | |
| rs50514024 | 589 | S>P | No | EVA | |
| rs1134672984 | 594 | E>Q | No | EVA | |
| rs3389276405 | 595 | C>Y | No | EVA | |
| rs3389281527 | 667 | L>F | No | EVA | |
| rs3389268280 | 667 | L>W | No | EVA | |
| rs3410464753 | 679 | V>F | No | EVA | |
| rs3389264347 | 722 | V>M | No | EVA | |
| rs3389239307 | 729 | P>Q | No | EVA | |
| rs3403787462 | 744 | I>TEHVSLISTFRLEAKLL* | No | EVA | |
| rs3389262284 | 745 | N>K | No | EVA | |
| rs3389281529 | 750 | V>M | No | EVA | |
| rs3389273491 | 770 | E>D | No | EVA | |
| rs3389268232 | 779 | K>E | No | EVA | |
| rs3403812454 | 792 | A>P | No | EVA | |
| rs3389262245 | 802 | S>N | No | EVA | |
| rs247940997 | 803 | G>E | No | EVA | |
| rs3389276413 | 804 | N>T | No | EVA | |
| rs3389264367 | 808 | F>I | No | EVA | |
| rs3389239302 | 822 | R>M | No | EVA | |
| rs3389197414 | 830 | K>* | No | EVA | |
| rs3389262312 | 850 | E>G | No | EVA | |
| rs51674769 | 861 | E>G | No | EVA | |
| rs264596851 | 893 | D>E | No | EVA | |
| rs3403909945 | 967 | Q>L | No | EVA | |
| rs3389197472 | 1000 | H>Q | No | EVA | |
| rs3389268054 | 1003 | L>F | No | EVA | |
| rs3389268054 | 1003 | L>V | No | EVA | |
| rs3389273461 | 1030 | P>L | No | EVA | |
| rs47790395 | 1058 | V>L | No | EVA | |
| rs3389268058 | 1064 | C>G | No | EVA | |
| rs3389276335 | 1074 | V>A | No | EVA | |
| rs46742826 | 1101 | T>A | No | EVA | |
| rs3389239296 | 1131 | T>S | No | EVA | |
| rs258586564 | 1138 | P>S | No | EVA |
No associated diseases with Q6DFV1
No regional properties for Q6DFV1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q6DFV1 | |||
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| condensed nuclear chromosome | A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome. |
| condensin complex | A multisubunit protein complex that plays a central role in chromosome condensation in meiosis and mitosis. |
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| bHLH transcription factor binding | Binding to a basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways. |
| enzyme activator activity | Binds to and increases the activity of an enzyme. |
| histone deacetylase regulator activity | Binds to and modulates the activity of histone deacetylase. |
| methylated histone binding | Binding to a histone in which a residue has been modified by methylation. |
| transmembrane receptor protein tyrosine kinase inhibitor activity | Binds to and stops, prevents or reduces the activity of a transmembrane receptor protein tyrosine kinase. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| chromosome condensation | The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. |
| erythrocyte differentiation | The process in which a myeloid precursor cell acquires specializes features of an erythrocyte. |
| inner cell mass cell proliferation | The proliferation of cells in the inner cell mass. |
| mitotic sister chromatid segregation | The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets. |
| positive regulation of chromosome condensation | Any process that activates or increases the frequency, rate or extent of chromosome condensation. |
| positive regulation of chromosome segregation | Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. |
| positive regulation of chromosome separation | Any process that activates or increases the frequency, rate or extent of chromosome separation. |
| transcription by RNA polymerase II | The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q86XI2 | NCAPG2 | Condensin-2 complex subunit G2 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEKREAFIQA | VSKELVEEFL | QFLQLDKDSS | NPFSLSELLD | ELSRKQKEEL | WQRLKDLLTE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TLLESPVDRW | QTVEVEGADD | MESEHSPKMR | KSIKIICAIV | TVILASVSII | NEHENYGALL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ECAVILNGIL | YALPESEQKL | QNSIQDLCVK | WWERGLPAKE | DMGKTAFIML | LRRSLETKSG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ADVCRLWRIH | QALYCFDYDW | EESREIKDML | LECFINVNYI | KKEEGRRFLS | FLFSWNVDFI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KMIHETIKNQ | LAGLQKSLMV | HIAEIYFRAW | KKASGKMLET | IEYDCIQDFM | FHGIHLLRRS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PVHSKVREVL | SYFHQQKVRQ | GVEEMLYRLY | KPILWRGLKA | RNSEVRSNAA | LLFVEAFPIR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DPNFTATEMD | NEIQKQFEEL | YNLIEDPYPR | VRSTGILGVC | KISSKYWEMM | PPNILVDFLK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KVTGELAFDI | SSADVRCSVF | KCLPIILDNK | LSHPLLEQLL | PTLRYSLHDN | SEKVRVAFVD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LLLKIKAVRA | AKFWKICPME | DILVRLEMDS | RPVSRRLVSL | IFNSFLPVNQ | PEEVWCERCV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TLIQMNRAAA | RRFYQYAHEH | TASTNIAKLI | HVIRHCLNAC | IQRTLREGSE | AHKECEKENA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SVLDKTLSVN | DTASMAGLLE | IIVILWKNIH | RSLENNKEAK | IYTINKFAAV | LPEYLKVFKD |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ERCKIPLFML | MSFLPASAVP | VFSCGVISVL | RNQESVTGRS | YCTLLDCLCS | WGQVGHVLEL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| IVDWLPTVPP | QAKSNLASKR | KVEINDTCSV | KPELALLYME | YLLTHPKNRE | CLLSVPQKKL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| NQLLKALEGS | KAELESFLQS | PSGNPLNFNK | ATALHAFGLY | CRMSVHLQYK | FCSEEKIHLS |
| 850 | 860 | 870 | 880 | 890 | 900 |
| ILDDTGSWLE | NKVLPLLEDQ | EEEYLKLRKD | VYQQIIQTYL | AVCKDVVMVG | LGDPKFQMQL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| LQRSFGIMKT | VKGFFYVSLL | LGILKEIAGN | TIIHKTDSDE | KVTVLFDLVQ | EVFQKMLECI |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| ACIFRKQPEE | SLPLFHSVQT | PLHEFITTIQ | SWHKDTAVHH | AVLSTLIAAP | VVEISHQLQK |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| VSDIEELTSP | QCLHDLPPFS | RCLVGVIMKS | SDVVRSFVDE | LKACVTSGDV | EGIVCLTAVL |
| 1090 | 1100 | 1110 | 1120 | 1130 | |
| HIILVINKGK | HISAKVKEVA | TAVYRKLKTF | MEITLEEDSL | ERFLYESSMR | TLGEFLNP |