Q6DFA8

PR
Gene name
tent2-b
Protein name
Poly(A) RNA polymerase GLD2-B
Names
xGLD-2, PAP-associated domain-containing protein 4-B
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:446415
EC number
2.7.7.19: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

62-138 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6DFA8

Entry ID Method Resolution Chain Position Source
AF-Q6DFA8-F1 Predicted AlphaFoldDB

No variants for Q6DFA8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6DFA8

No associated diseases with Q6DFA8

2 regional properties for Q6DFA8

Type Name Position InterPro Accession
domain PAP/25A-associated 409 - 462 IPR002058
domain Polymerase, nucleotidyl transferase domain 210 - 267 IPR002934

Functions

Description
EC Number 2.7.7.19 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template, via extension of the 3'-end.
adenylyltransferase activity Catalysis of the transfer of an adenylyl group to an acceptor.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
polynucleotide adenylyltransferase activity Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group.

4 GO annotations of biological process

Name Definition
mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
negative regulation of miRNA catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of miRNA catabolic process.
oogenesis The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
RNA stabilization Prevention of degradation of RNA molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MYPNSPSLGR IPLPLPCARQ QQTSAYLSKV PVSVAPDLLS PEQFFQASLN IHKNANLPRL
70 80 90 100 110 120
LMNGNVLTVP PLSSPPWSYL NHSPLISPGS PPSSFQNRKR RSDEGNSPYD VKRQRFQSPQ
130 140 150 160 170 180
EQTVNHQAVP LRGDIRCSYP GSPAFPLLQS PSPPVLKGHS SNSGDCWLYD HIDTTLPVAK
190 200 210 220 230 240
DKLSKQILDL FQALQQQVCD LKKKDICRAE LQREIQQIFP QSRLYLVGSS LNGFGIRSSD
250 260 270 280 290 300
ADLCLVLKEE PMNQNTEARH ILSLLHKHFY TRLSYIERPQ FIRAKVPIVK FRDKVSGAEF
310 320 330 340 350 360
DLNVNNVVGI RNTFLLRTYA YLDKRVRPLV LVIKKWANHH GINDASRGTL SSYTIVLMVL
370 380 390 400 410 420
HYLQTLPEPI LPSLQKKYPE CFDRTMQLHL VHQAPRNIPQ FLSKNETPLG DLLLGFLKYF
430 440 450 460 470 480
AVEFDWSKDI ISLREAKALP RTDDYEWRNK YICVEEPFDG SNTARAVYEK QKFDLIRAEF
490 500
LKAWVALRDN RDLYSLLPVK GIMKKMHSL