Q6DFA1

PR
Gene name
dcun1d3
Protein name
DCN1-like protein 3
Names
DCNL3, DCUN1 domain-containing protein 3, Defective in cullin neddylation protein 1-like protein 3
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:446419
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-63 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6DFA1

Entry ID Method Resolution Chain Position Source
AF-Q6DFA1-F1 Predicted AlphaFoldDB

No variants for Q6DFA1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6DFA1

No associated diseases with Q6DFA1

1 regional properties for Q6DFA1

Type Name Position InterPro Accession
domain Potentiating neddylation domain 85 - 277 IPR005176

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane
  • Cytoplasm
  • Nucleus
  • Cytoplasm, perinuclear region
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
cullin family protein binding Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3).

4 GO annotations of biological process

Name Definition
negative regulation of protein neddylation Any process that stops, prevents or reduces the frequency, rate or extent of protein neddylation.
positive regulation of protein neddylation Any process that activates or increases the frequency, rate or extent of protein neddylation.
regulation of cell cycle process Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
regulation of protein neddylation Any process that modulates the frequency, rate or extent of protein neddylation.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGQCVTKCKN PSSTLGSKNG ERESSKPHKR SSSHKEEHMS ICGKASGEIL VNGTKKGDAS
70 80 90 100 110 120
LEASQPLAVG VDTKKKEQGV GAELSSLQRI EELFRRYKDE REDAILEEGM ERFCDDLCVD
130 140 150 160 170 180
PTEFRVLVLA WKFQAATMCK FTRREFFEGC KSINADGIES ICSQFPGLLN EAKQEDKFKD
190 200 210 220 230 240
LYRFTFQFGL DSEEGQRSLH REIAIALWKL VFTQNKPLIL DQWLEFLTEN PSGIKGISRD
250 260 270 280 290 300
TWNMFLNFTQ VIGPDLSNYS EDEAWPSLFD TFVEWEMERR KSEEKTDCIP CLGTDHQSRD
EQT