Q6DE87

PR
Gene name
chek1 (chk1)
Protein name
Serine/threonine-protein kinase Chk1
Names
CHK1 checkpoint homolog, Checkpoint kinase-1, xChk1
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:398191
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

309-386 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

147-172 (Activation loop from InterPro)

Target domain

9-265 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q6DE87

Entry ID Method Resolution Chain Position Source
AF-Q6DE87-F1 Predicted AlphaFoldDB

No variants for Q6DE87

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6DE87

No associated diseases with Q6DE87

4 regional properties for Q6DE87

Type Name Position InterPro Accession
domain Protein kinase domain 9 - 265 IPR000719
active_site Serine/threonine-protein kinase, active site 126 - 138 IPR008271
binding_site Protein kinase, ATP binding site 15 - 38 IPR017441
domain Checkpoint kinase 1, catalytic domain 7 - 265 IPR034670

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Nucleus
  • Chromosome
  • Cytoplasm
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
condensed nuclear chromosome A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
histone kinase activity (H3-T11 specific) Catalysis of the transfer of a phosphate group to the threonine-11 residue of the N-terminal tail of histone H3.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

12 GO annotations of biological process

Name Definition
cellular response to DNA damage stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
DNA damage checkpoint signaling A signal transduction process that contributes to a DNA damage checkpoint.
DNA damage induced protein phosphorylation The widespread phosphorylation of various molecules, triggering many downstream processes, that occurs in response to the detection of DNA damage.
epigenetic maintenance of chromatin in transcription-competent conformation An epigenetic process that capacitates gene expression by remodelling of chromatin by either modifying the chromatin fiber, the nucleosomal histones, or the DNA.
mitotic G2 DNA damage checkpoint signaling A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage.
negative regulation of mitotic nuclear division Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother.
peptidyl-threonine phosphorylation The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of double-strand break repair via homologous recombination Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences.
regulation of histone H3-K9 acetylation Any process that modulates the frequency, rate or extent of histone H3-K9 acetylation.
regulation of mitotic centrosome separation Any process that modulates the frequency, rate or extent of the separation of duplicated centrosome components at the beginning of mitosis.
regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a UV damage stimulus.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAVPFVEDWD LVQTLGEGAY GEVQLAVNRK TEEAVAVKIV DMTRAADCPE NIKKEICINR
70 80 90 100 110 120
MLSHTNIVRF YGHRREGNIQ YLFLEYCRGG ELFDRIEPDV GMPEQDAQKF FQQLIAGVEY
130 140 150 160 170 180
LHSIGITHRD IKPENLLLDE RDQLKISDFG LATVFRHNGK ERLLNKMCGT LPYVAPELIK
190 200 210 220 230 240
SRAFHADPVD VWSCGIVLTA MLAGELPWDQ PNEVCQEYCD WKEKNHYLTP WKKISATPLA
250 260 270 280 290 300
LLCKMLTENP QSRITIPDIK KDRWFTEIIK KGLKRSRVIS GGSSDSSVLC KQIRSDIDIS
310 320 330 340 350 360
HFSHSEEKTA LSSTQPEPRT ALATWDSNSS YIDNLVQGKG ISFSQPACPD NMLLNSQLIG
370 380 390 400 410 420
TPGSSQNVWQ RLVKRMTRFF TKVNAESSYS NLMDTCEKMG YVLKKSCANE VTLSTTDRRN
430 440 450 460 470
NKLIFKVNLV EMEDRILLDF RLSKGDGLEF KRHFLKIKKK MDAVVAVQKV LPDT