Q6DE00

PR
Gene name
dph2
Protein name
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2
Names
Diphthamide biosynthesis protein 2, Diphtheria toxin resistance protein 2, S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:446553
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

383-454 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6DE00

Entry ID Method Resolution Chain Position Source
AF-Q6DE00-F1 Predicted AlphaFoldDB

No variants for Q6DE00

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6DE00

No associated diseases with Q6DE00

1 regional properties for Q6DE00

Type Name Position InterPro Accession
domain Formin, FH2 domain 1 - 295 IPR015425

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

2 GO annotations of molecular function

Name Definition
2-(3-amino-3-carboxypropyl)histidine synthase activity Catalysis of the reaction S-adenosyl-L-methionine + L-histidine- = S-methyl-5-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.

1 GO annotations of biological process

Name Definition
peptidyl-diphthamide biosynthetic process from peptidyl-histidine The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAAALFSSNG EEAIGRNIDI GQVDIQSSPE KDLGEFYEIE KTVEFIQRNA AQKVALQFPD
70 80 90 100 110 120
DLLLDSVKVA RKLEEATGAK TYILGDTSYG SCCVDEVAAE HVKANVLVHY GRACLSPCCR
130 140 150 160 170 180
LPVSYVFGRK AVNMDLCAEA FLSHYRDTES HVVVLSDVVY DHALGELAKR IRSAYPNVIF
190 200 210 220 230 240
SKLTSCGETA SPDEIVKFGR RFSPDLRLWP ESYGIFYVGG EGSTLNNLML TWPRCSFFSF
250 260 270 280 290 300
NPFTGEGRTE GLHVNRALMI RFYLIERARD AHVFGILVGT LGVSDYLSAL KHLKNIIHLA
310 320 330 340 350 360
GKKSYMFSVG KLNPAKLANF PEIDVFVLVA CPENSLLDSS EFYKPVVTPD EMEIACNPAR
370 380 390 400 410 420
EWHGYCITNF RELLPGGSAY VEFPETDPSD AHHTDVSLIT GNLRSSHLTV AETLEKDSDT
430 440 450 460 470
SLVQRNSKTA LAQMSSAASY LASRSWQGLD KALGQTPVVK AVEGRKGIAI AYEDEICS