Q6DDT1
Gene name |
isyna1-b (ino1-b) |
Protein name |
Inositol-3-phosphate synthase 1-B |
Names |
IPS 1-B, Myo-inositol 1-phosphate synthase B, MI-1-P synthase B, MIP synthase B |
Species |
Xenopus laevis (African clawed frog) |
KEGG Pathway |
xla:446618 |
EC number |
5.5.1.4: Intramolecular lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6DDT1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6DDT1-F1 | Predicted | AlphaFoldDB |
No variants for Q6DDT1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6DDT1 | |||||
No associated diseases with Q6DDT1
1 regional properties for Q6DDT1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Myo-inositol-1-phosphate synthase, GAPDH-like | 304 - 417 | IPR013021 |
Functions
| Description | ||
|---|---|---|
| EC Number | 5.5.1.4 | Intramolecular lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| inositol-3-phosphate synthase activity | Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| inositol biosynthetic process | The chemical reactions and pathways resulting in the formation of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. |
| phospholipid biosynthetic process | The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAEMFKVESP | HVRYLKDVIE | ADYSYDTTQV | YEEKGVTKVK | PCSTKFTFHT | ERKVPKLGVM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LVGWGGNNGT | TVTAAVLANR | LGLSWMTKTG | KKVANYYGSL | FQSSTVCLGR | GSSGEVFVPF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RDLLPMVNPN | DLVFDGWDIS | SLNLADAMFR | AEVLDWQLQE | QLRPYMEKMK | PRPSIYIPEF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IAANQEDRAD | HTIHGTKAEQ | VQKIREDIQD | FKRTSGVDKV | IVLWTANTER | FCDIIPGVND |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TADNLLKAIE | NGLEVSPSTM | FAVASILEGC | AFINGSPQNT | FVPGAIELAI | RHNVFIGGDD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FKSGQTKIKS | VLMDFLVSAG | LKPVSIVSYN | HLGNNDGKNL | SAPQQFRSKE | ISKSNVVDDM |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VQSNPILYGP | NEKPDHCVVI | KYVPYVGDSK | RAMDEYTSEI | MMGGANTIVL | HNTCEDSLLA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SPIFLDLVLL | TELCQRITFR | TETDQEFQTF | HSVLSILSFL | CKAPLVPAGT | PVVNAFFRQR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NCIENILRAC | LGLSPQNHMM | LEHKMQRSFV | SLKRPSVDCN | AYPISSKKGN | GVNGFHPPGI |
| 550 | 560 | ||||
| SNGLSHSNGL | GKTVISSDIE | IEN |