Q6DDF4
Gene name |
vps36 |
Protein name |
Vacuolar protein-sorting-associated protein 36 |
Names |
ESCRT-II complex subunit VPS36 |
Species |
Xenopus laevis (African clawed frog) |
KEGG Pathway |
xla:446727 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6DDF4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6DDF4-F1 | Predicted | AlphaFoldDB |
No variants for Q6DDF4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6DDF4 | |||||
No associated diseases with Q6DDF4
1 regional properties for Q6DDF4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Vacuolar protein sorting protein 36, GLUE domain | 1 - 138 | IPR021648 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| ESCRT II complex | An endosomal sorting complex required for transport and functions downstream of ESCRT I complex. It consists of the class E vacuolar protein sorting (Vps) proteins and is required for the membrane recruitment of ESCRT III complex and binds to ubiquitinated cargoes. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| mRNA 3'-UTR binding | Binding to a 3' untranslated region of an mRNA molecule. |
| phosphatidylinositol-3-phosphate binding | Binding to phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position. |
| ubiquitin binding | Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| endosome transport via multivesicular body sorting pathway | The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDRFSWCTGL | LDIDETLVIQ | QRGVRLSDGE | EKTKFDSGTL | LLTTHRLIWR | DQKNHDFCIA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FPLSQIVFTE | EQAGGIGKSA | KIVVHLHPAT | PNKEPGPYQT | SRYSYVKLSF | REHGQIEFQR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RLAEELTQRR | WERLSASASP | SMQMNKGPQT | GRIKAVGIVG | IERKLEEKRK | ETDKNISEAF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EDLSKLMEKA | KEMVELSKSI | ATKIKDKQGD | ISEDETIRFK | SYLLSMGIAN | PVTRETHGSG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| THYHMQLAKQ | LATMLQAPLE | ERGGIMSLTE | VYCLVNRARG | MELLSPEDLV | NACKMLESLK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LPIRLRVFDS | GVMVIEHQSH | NEEEMVASAL | ETVSEKGSLT | SEEFAKIVGM | SVLLAKERLL |
| 370 | 380 | ||||
| LAENMGHLCR | DDSVEGLRFY | PNLFLTQS |