Q6DCQ8

PR
Gene name
pi4k2b (TGas067g11.1)
Protein name
Phosphatidylinositol 4-kinase type 2-beta
Names
Phosphatidylinositol 4-kinase type II-beta
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:446885
EC number
2.7.1.67: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-129 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6DCQ8

Entry ID Method Resolution Chain Position Source
AF-Q6DCQ8-F1 Predicted AlphaFoldDB

No variants for Q6DCQ8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6DCQ8

No associated diseases with Q6DCQ8

7 regional properties for Q6DCQ8

Type Name Position InterPro Accession
domain Cyclic nucleotide-binding domain 204 - 334 IPR000595-1
domain Cyclic nucleotide-binding domain 336 - 452 IPR000595-2
domain cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain 5 - 43 IPR003117
conserved_site Cyclic nucleotide-binding, conserved site 232 - 248 IPR018488-1
conserved_site Cyclic nucleotide-binding, conserved site 280 - 297 IPR018488-2
conserved_site Cyclic nucleotide-binding, conserved site 363 - 379 IPR018488-3
conserved_site Cyclic nucleotide-binding, conserved site 399 - 416 IPR018488-4

Functions

Description
EC Number 2.7.1.67 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Cytoplasm, cytosol
  • Golgi apparatus membrane ; Peripheral membrane protein
  • Endoplasmic reticulum membrane
  • Cell membrane
  • Early endosome membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
early endosome membrane The lipid bilayer surrounding an early endosome.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
1-phosphatidylinositol 4-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

2 GO annotations of biological process

Name Definition
phosphatidylinositol phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEQKQTTEPR DSPPLLVLLD PAAEQLEVSA PHTPLSPQPQ SARAAPGSAV RFFCDSAREE
70 80 90 100 110 120
EAGEDEPLLK KPGPMSPRAV RKGRTRLSSS SDDRENMSSG HVENGEYNVI LNDPEFADII
130 140 150 160 170 180
HRAEQAIESG VFPERISQGS SGSYFVKDPK GKIIGVFKPK SEEPYGHLNP KWTKYFHKIC
190 200 210 220 230 240
CPCCFGRGCL VPNQGYLSEA GAYLVDEKLG LGVVPKTKAV WLVSETFNYS AIDRAKSRGK
250 260 270 280 290 300
KYALEKVPKV GKKFHRIGLP PKVGSFQLFV DGYKEADYWL RKFETDPLPE NTRKQLQSPF
310 320 330 340 350 360
EKLVILDYVI RNTDRGNDNW LIRYDSQDDD ELSEKGDSFP LKDWKEIKEP IIKIAAIDNG
370 380 390 400 410 420
LAFPFKHPDE WRAYPFHWAW LPQAKVPFSQ ETRDLILPRI SDMNFIQDLC EDLYELFKTD
430 440 450 460 470 480
KGFDKDTFEK QMSVMRGQIL NLTQALKDGK TPIQLVQMPR VVVERSYSGS QGRIVQMSNA
490
FTQTFHCRKP FFSSW