Q6DCK1

PR
Gene name
lpcat4 (agpat7, aytl3)
Protein name
Lysophospholipid acyltransferase LPCAT4
Names
1-acylglycerol-3-phosphate O-acyltransferase 7, 1-AGP acyltransferase 7, 1-AGPAT 7, 1-acylglycerophosphocholine O-acyltransferase, 1-acylglycerophosphoserine O-acyltransferase, 1-alkenylglycerophosphoethanolamine O-acyltransferase, 1-alkylglycerophosphocholine O-acetyltransferase, Acyltransferase-like 3, Lysophosphatidylcholine acyltransferase 4, Lysophosphatidylethanolamine acyltransferase 2
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:446240
EC number
2.3.1.23: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

468-522 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6DCK1

Entry ID Method Resolution Chain Position Source
AF-Q6DCK1-F1 Predicted AlphaFoldDB

No variants for Q6DCK1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6DCK1

No associated diseases with Q6DCK1

2 regional properties for Q6DCK1

Type Name Position InterPro Accession
domain Phospholipid/glycerol acyltransferase 119 - 235 IPR002123
domain Lysophosphatidylcholine acyltransferase LPCAT1-like 99 - 305 IPR045252

Functions

Description
EC Number 2.3.1.23 Transferring groups other than amino-acyl groups
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

5 GO annotations of molecular function

Name Definition
1-acylglycerophosphocholine O-acyltransferase activity Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA.
1-acylglycerophosphoethanolamine O-acyltransferase activity Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA.
1-acylglycerophosphoserine O-acyltransferase activity Catalysis of the reaction:a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA.
1-alkenylglycerophosphoethanolamine O-acyltransferase activity Catalysis of the reaction: 1-alkenylglycerophosphoethanolamine + acyl-CoA = 1-alkenyl-2-acyl-glycerophosphoethanolamine + CoA.
1-alkylglycerophosphocholine O-acetyltransferase activity Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA.

1 GO annotations of biological process

Name Definition
phospholipid biosynthetic process The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSEADPVGEK GPAEDDGEES VPFNPFLHEF EPKGLWQNAR FYILGPILFP LRFLLAAVFL
70 80 90 100 110 120
FLMWPIAALR VAGLTDKELS CSIRHRRTIL HHLIYLLSRT MFFMCGFHWI TIRGRRAPAS
130 140 150 160 170 180
EAPILVVAPH STFFDPIVTV VCDLPSVVSR VENLNIPVIG ALLRFNQSIL VSRQDPSSRK
190 200 210 220 230 240
KVVEEVKRRA TSNGEWPQVL FFPEGTNGNG KVLLKFKPGA FVAGVPVQPV LMRYPNKLPA
250 260 270 280 290 300
TIWTWKGNGV FKVLWLTMSQ FYINLEIEFL PVYHPTAEER ADPTLYAFKV QKIMADALAK
310 320 330 340 350 360
PATEFELIGD TPVSPLGHLK VALDPKIWEL GNILKKAGFS LDSVQGLIDL CLEGVCSRVG
370 380 390 400 410 420
LDELAEKLGV TQHDVISRVF NYFNKDAAGM IDFREVSLVL AAQDATRSAE ELAKLAFDLF
430 440 450 460 470 480
STCDADGRSL LSADGFASVL RSLLGSPPAE SGKVFTELYT YTELQGLTQD GFVRFAIRHP
490 500 510 520
CYRHLFLFYL RPPSSGRRKP PQIQQNGGCS GKNNPGKQSK MD