Q6DBR6

PR
Gene name
stac3
Protein name
SH3 and cysteine-rich domain-containing protein 3
Names
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:445111
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

91-243 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6DBR6

Entry ID Method Resolution Chain Position Source
AF-Q6DBR6-F1 Predicted AlphaFoldDB

No variants for Q6DBR6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6DBR6

No associated diseases with Q6DBR6

3 regional properties for Q6DBR6

Type Name Position InterPro Accession
domain SH3 domain 217 - 276 IPR001452-1
domain SH3 domain 277 - 334 IPR001452-2
domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain 62 - 113 IPR002219

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cell membrane, sarcolemma ; Peripheral membrane protein ; Cytoplasmic side
  • Cell membrane, sarcolemma, T-tubule
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extrinsic component of cytoplasmic side of plasma membrane The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
T-tubule Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
voltage-gated calcium channel complex A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential.

1 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.

6 GO annotations of biological process

Name Definition
positive regulation of protein localization to plasma membrane Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
positive regulation of voltage-gated calcium channel activity Any process that activates or increases the frequency, rate or extent of voltage-gated calcium channel activity.
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Any process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels.
skeletal muscle contraction A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control.
skeletal muscle tissue development The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.
T-tubule organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of the T-tubule. A T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q96MF2 STAC3 SH3 and cysteine-rich domain-containing protein 3 Homo sapiens (Human) PR
10 20 30 40 50 60
MAQYDQLEDK DSLDIHDNPP APENVVKEDD NTVYFVYDEE VEEEEAPPPP TPEPIVQVND
70 80 90 100 110 120
KPHKFKDHYC KKPKFCDVCA RMIVLNNKFA LRCKNCKTNI HHSCQSYVQF QRCFGKIPPG
130 140 150 160 170 180
FRRAYSSPLY DQEINNPGQQ NRTDPVFDTL RVGVIMANKE RKKGSEDKKN MMMMMMEEEE
190 200 210 220 230 240
AQQPKEDEEG AEGKQDGDKK DKTATDDKNK KQQQTFSQSH YYMALYRFKA IEKDDLDFHP
250 260 270 280 290 300
GDRITVLDDS NEEWWRGKIG EKTGYLPMTY IIRVRAGERV YKVTRSFVGN REMGQITLKK
310 320 330
DQIVVKKGEE VNGYLKVSTG RKLGFFPADL LHEL