Q6D7H0

PR
Gene name
nei
Protein name
Endonuclease 8
Names
DNA glycosylase/AP lyase Nei, DNA-(apurinic or apyrimidinic site) lyase Nei, Endonuclease VIII
Species
Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
KEGG Pathway
eca:ECA1355
EC number
4.2.99.18: Other carbon-oxygen lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

153-225 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6D7H0

Entry ID Method Resolution Chain Position Source
AF-Q6D7H0-F1 Predicted AlphaFoldDB

No variants for Q6D7H0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6D7H0

No associated diseases with Q6D7H0

2 regional properties for Q6D7H0

Type Name Position InterPro Accession
domain FeS cluster biogenesis 2 - 98 IPR000361
domain NIF system FeS cluster assembly, NifU, C-terminal 111 - 175 IPR001075

Functions

Description
EC Number 4.2.99.18 Other carbon-oxygen lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
class I DNA-(apurinic or apyrimidinic site) endonuclease activity Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate.
damaged DNA binding Binding to damaged DNA.
oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPEGPEIRRA ADKLVEAVVG KTLTRVWFAF PELKPYETEL VGQQVRQIET RGKALLTYFS
70 80 90 100 110 120
HDRVLYSHNQ LYGVWRVVNA GESPETKRDL RIRLETQDRA ILLYSASDIE MLTLDTLTAH
130 140 150 160 170 180
PFLQRIGPDV LDLSLTPEQV CERLLLPRFR RRQFSGLLLD QAFLAGLGNY LRVEILWQAQ
190 200 210 220 230 240
LAPQHTASQL NEEQLQTLSR ALLEIPRLSY NTRGTVDENR HHGAIFSFKV FHREGESCER
250 260
CGGTIERTML SSRPFYWCPH CQS