Q6D437

PR
Gene name
msbA
Protein name
ATP-dependent lipid A-core flippase
Names
Lipid A export ATP-binding/permease protein MsbA
Species
Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
KEGG Pathway
eca:ECA2557
EC number
7.5.2.6: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

198-275 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6D437

Entry ID Method Resolution Chain Position Source
AF-Q6D437-F1 Predicted AlphaFoldDB

No variants for Q6D437

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6D437

No associated diseases with Q6D437

4 regional properties for Q6D437

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 342 - 578 IPR003439
domain AAA+ ATPase domain 368 - 555 IPR003593
domain ABC transporter type 1, transmembrane domain 28 - 310 IPR011527
conserved_site ABC transporter-like, conserved site 481 - 495 IPR017871

Functions

Description
EC Number 7.5.2.6 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Cell inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
ABC-type transporter activity Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATPase-coupled lipid transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipid(in) = ADP + phosphate + lipid(out).

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLNDKDLSTW QTFRRLWPMI SPFKAGLAVA AIALIINAAG DTLMLSLLKP LLDEGFGKAD
70 80 90 100 110 120
RSVLLWMPLV VIGLMLVRGA SGFVSSYCVS WVSGKVVMNM RRRLFSHIMG MPVAFFDQQS
130 140 150 160 170 180
TGTLLSRITY DSEQVAASSS GALITVVREG ASIIGLFILM FYYSWQLSII LIVIAPIVSI
190 200 210 220 230 240
AMRMVSKRFR SISKNMQDTM GHVTTSTEQM LKGHKEVLMF GGQDVETKRF EQVSNRMRQQ
250 260 270 280 290 300
GMKMVSASSI SDPIIQLIAS LALAFVLYAA SFPSVMETLT AGTITVVFSS MIALMRPLKS
310 320 330 340 350 360
LTNVNAQFQR GMAACQTLFA ILDMEQERDT GKREIERAKG ELEFRQVNFA YPARENLALK
370 380 390 400 410 420
NINLHIPVGK TVALVGRSGS GKSTIASLIT RFYDIQSGEI LLDGHDLREY RLSSLRNQVA
430 440 450 460 470 480
LVSQNVHLFN DTIANNIAYA RNENYSREEI ERAAKMAYAM DFINKMEHGL DTVIGENGVM
490 500 510 520 530 540
LSGGQRQRIA IARALLRDSP ILILDEATSA LDTESERAIQ AALDELQKDR TALVIAHRLS
550 560 570 580
TIEKADEILV VEDGRIIERG NHTALLATNG AYAQLHRMQF GE