Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q6D3A9

Entry ID Method Resolution Chain Position Source
AF-Q6D3A9-F1 Predicted AlphaFoldDB

No variants for Q6D3A9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6D3A9

No associated diseases with Q6D3A9

14 regional properties for Q6D3A9

Type Name Position InterPro Accession
domain Leucine-rich repeat N-terminal domain 31 - 63 IPR000372
domain Cysteine-rich flanking region, C-terminal 160 - 208 IPR000483
domain Protein kinase domain 538 - 814 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 539 - 809 IPR001245
repeat Leucine-rich repeat 104 - 160 IPR001611
conserved_site Tyrosine-protein kinase, receptor class II, conserved site 703 - 711 IPR002011
domain Immunoglobulin subtype 216 - 302 IPR003599
domain Immunoglobulin-like domain 210 - 300 IPR007110
active_site Tyrosine-protein kinase, active site 675 - 687 IPR008266
domain Immunoglobulin I-set 323 - 391 IPR013098
domain Immunoglobulin-like beta-sandwich domain 218 - 296 IPR013151
binding_site Protein kinase, ATP binding site 544 - 572 IPR017441
domain Tyrosine-protein kinase, catalytic domain 538 - 810 IPR020635
domain Growth factor receptor NTRK, leucine rich repeat C-terminal 163 - 208 IPR031635

Functions

Description
EC Number 7.4.2.10 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Cell inner membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

1 GO annotations of biological process

Name Definition
peptide transport The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSSPVPGLML PEKRVVEVRN LSVYFEQQGQ RTDAVRNLTF SVDRGETLAI VGESGSGKSV
70 80 90 100 110 120
TSLALMRLVE HAGGVIHQGD MLFRRRDGQV LDLRGARQRV MRTLRGADLA MIFQEPMTSL
130 140 150 160 170 180
NPVFPVGEQI AESIRLHQRM DRRAARAETL RMLDLVRIPE ARNVLDRYPH QLSGGMRQRV
190 200 210 220 230 240
MIAMALSCKP SLLIADEPTT ALDVTIQAQI LQLIRVLQRE MDMAVIFITH DMGVVAEVAE
250 260 270 280 290 300
RVLVMHRGES VEAASVGQIF AAPQHPYTQG LLAAVPALGS MRGQPFPAKF PLLDQNTARI
310 320 330 340 350 360
VDNVPQDTVP AHAEPILQVS NLVTRFPIRS GLLNRVTRQV HAVEKVSFDL WPGETLSLVG
370 380 390 400 410 420
ESGCGKSTTG RALLQLVESQ KGDITFDGQR IHQLKGAALQ HLRRDIQLIF QDPYASLDPR
430 440 450 460 470 480
LTVGFSIMEP LLVHNVCRRQ EAEKRVAWLL SRVGLEPEHA RRYPHEFSGG QRQRVCIARA
490 500 510 520 530 540
LALNPKVVIA DEAVSALDVS IQAQIINLML ELQREFGIAF LFISHDMAVV ERISHRVAVM
550 560 570 580 590 600
YMGQIVEIGP RQDVFERPQH PYTRKLMSAV PVADPSRRQR EQVLLVDEIP SPIRAIGDEP
610 620
TTAPLVQVGK RHFVAHHPIA GAY