Q6CXX3

PR
Gene name
HIR1 (KLLA0A04928g)
Protein name
Protein HIR1
Names
Species
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
KEGG Pathway
kla:KLLA0_A04928g
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

419-508 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6CXX3

Entry ID Method Resolution Chain Position Source
AF-Q6CXX3-F1 Predicted AlphaFoldDB

No variants for Q6CXX3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6CXX3

No associated diseases with Q6CXX3

8 regional properties for Q6CXX3

Type Name Position InterPro Accession
repeat WD40 repeat 5 - 46 IPR001680-1
repeat WD40 repeat 65 - 113 IPR001680-2
repeat WD40 repeat 123 - 204 IPR001680-3
repeat WD40 repeat 264 - 328 IPR001680-4
repeat WD40 repeat 331 - 371 IPR001680-5
domain Protein HIRA-like, C-terminal 733 - 810 IPR011494
conserved_site HIRA B motif 493 - 512 IPR019015
conserved_site WD40 repeat, conserved site 91 - 105 IPR019775

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
chromosome, centromeric region The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
HIR complex A protein complex proposed to be involved in replication-independent nucleosome assembly, by promoting histone deposition onto DNA. For example, in Saccharomyces, the complex contains Hir1p, Hir2p, Hir3p, and Hpc2p.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
identical protein binding Binding to an identical protein or proteins.
nucleosome binding Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.
transcription corepressor activity A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

5 GO annotations of biological process

Name Definition
negative regulation of chromatin organization Any process that stops, prevents or reduces the frequency, rate or extent of chromatin organization.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
negative regulation of transcription by RNA polymerase III Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase III.
nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
transcription elongation by RNA polymerase II promoter The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKLLKLPWLQ HREEHKSYEV YTCDVSPDSQ RLATGGLDGK IRIWSIPDIL KFASNPNAST
70 80 90 100 110 120
DKDILMKPLS TMSRHAGSVT TVKFSPDGKY LASGSDDRIL LIWELEGGTT QPMFGAESTD
130 140 150 160 170 180
IEHWNVRRRL VAHDNDIQDI CWAPDSSIMV SVGLDRAIII WNGSTFEKVK RFDVHQSHVK
190 200 210 220 230 240
GVVFDPANKY FATASDDRTI KMFRYHKTGE TSFSVEHVIT EPFKGSPLTT YFRRLSWSPD
250 260 270 280 290 300
GQHIAAPNAM NGPVSTVAII ERGTWESPVS LVGHDQPTEV ASFNPRIFKR QKDDSTTDTI
310 320 330 340 350 360
DGKKTGISDE VDCIVASSGQ DKTLAVWSTS KARPLIVAQD ICGKSITDMS WTPDGKILFI
370 380 390 400 410 420
TSLDSSIVVL TFEDNEFGEA IPLEQNIEYL HRYGVDKDSL VFPETVEQLI LEDQAKNLKK
430 440 450 460 470 480
SNVDMNLLEN RLGKPGTIAE PNILQVRSKK RAQLTGTGNH TDNNTTSKAE PPHVNILQVK
490 500 510 520 530 540
RKNKVTGVTE VLHDTVVKNG KKRVAPTLIT MGHSPDKSRK RVILSTAQSL NNTVQPTTKP
550 560 570 580 590 600
APEEKSTLAK LQSTKLSKPS FSIPRLGIHT LIMGFKERTR ENFINQGSTD STVDESNVNI
610 620 630 640 650 660
DEGPQQLEQN SAEEHLLTLN SKTTLEKIWR DEPNTRYLEF NSILPDADAV LREMGTIDDL
670 680 690 700 710 720
YVLEVRNGVE RSIQFDTEAL YDNSTRVLGY HAGQRSFELF FPDVVLTCVG CMETKTWILA
730 740 750 760 770 780
TTTGQLFFID TLGQARCPRI SIGHKIIKLC TSQSHVIAIT ETALIYVWDL VSMSLTLKNI
790 800 810 820 830 840
PLLPLLARDP ITGNRARFTS KIKSAKMTEN KDLQLVMTDI APDSDSNPST LHFLYSSSLS
850 860
CWCSPKEALL VDASVEQVIT S