Q6CXB7

PR
Gene name
HAS1 (KLLA0A09669g)
Protein name
ATP-dependent RNA helicase HAS1
Names
Species
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
KEGG Pathway
kla:KLLA0_A09669g
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-58 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6CXB7

Entry ID Method Resolution Chain Position Source
AF-Q6CXB7-F1 Predicted AlphaFoldDB

No variants for Q6CXB7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6CXB7

No associated diseases with Q6CXB7

7 regional properties for Q6CXB7

Type Name Position InterPro Accession
conserved_site ATP-dependent RNA helicase DEAD-box, conserved site 186 - 194 IPR000629
domain Helicase, C-terminal 255 - 425 IPR001650
domain DEAD/DEAH box helicase domain 58 - 230 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 53 - 259 IPR014001
domain RNA helicase, DEAD-box type, Q motif 34 - 62 IPR014014
domain Domain of unknown function DUF4217 416 - 479 IPR025313
domain DDX18/Has1, DEAD-box helicase domain 45 - 243 IPR044773

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
preribosome, large subunit precursor A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit.
small-subunit processome A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
identical protein binding Binding to an identical protein or proteins.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

3 GO annotations of biological process

Name Definition
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
snoRNA release from pre-rRNA The release of snoRNA from pre-rRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAGNKRVRDA ESEQDHAETE TVVKDTATTG EVEGSFSDLK LSDGTMKAIG KMGFTQMTAV
70 80 90 100 110 120
QTRTIPPLLA GKDVLGAAKT GSGKTLAFLI PAIEMLHSLK FKPRNGTGVI VITPTRELAL
130 140 150 160 170 180
QIFGVARELM EFHSQTFGIV IGGANRRQEA DKLMKGVNIL IATPGRLLDH LQNTKGFIFK
190 200 210 220 230 240
NLKALVIDEA DRILEIGFED EMRQIIKILP NEDRQSMLFS ATQTTKVEDL ARISLRPGPL
250 260 270 280 290 300
FINVDSEKDT STADGLEQGY VVCESDKRFL LLFSFLKRNQ KKKVIVFLSS CNSVKYYAEL
310 320 330 340 350 360
LNYIDLPVLE LHGKQKQQKR TNTFFEFCNA ERGILVCTDV AARGLDIPAV DWIIQFDPPD
370 380 390 400 410 420
DPRDYIHRVG RTARGTKGKG KSLMFLTPTE LGFLRYLKAA KVPLNEYEFP TNKIANVQAQ
430 440 450 460 470 480
LEKLIKSNYY LHQIAKDGYR SYLQAYASHS LKTVYQIDKL DLAKVAKSYG FPVPPKVNIT
490
IGASGKTPAT KKRRTKD