Q6CWQ5

PR
Gene name
MRH4 (KLLA0B02310g)
Protein name
ATP-dependent RNA helicase MRH4, mitochondrial
Names
Species
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
KEGG Pathway
kla:KLLA0_B02310g
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-130 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6CWQ5

Entry ID Method Resolution Chain Position Source
AF-Q6CWQ5-F1 Predicted AlphaFoldDB

No variants for Q6CWQ5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6CWQ5

No associated diseases with Q6CWQ5

3 regional properties for Q6CWQ5

Type Name Position InterPro Accession
domain Helicase, C-terminal 397 - 584 IPR001650
domain DEAD/DEAH box helicase domain 167 - 354 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 161 - 377 IPR014001

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
mitochondrial ribosomal large subunit rRNA binding Binding to a mitochondrial large ribosomal subunit RNA (LSU rRNA).
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

2 GO annotations of biological process

Name Definition
mitochondrial large ribosomal subunit assembly The aggregation, arrangement and bonding together of a set of components to form a mitochondrial large ribosomal subunit.
RNA metabolic process The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQPVFSRFPY ASKSGFISLA SRGYAVSRNS GSSIKSNLRS KPRADTRWNT KAKPPVKNRK
70 80 90 100 110 120
SNGKGDHRSH SRSDSRAKPS QEQTQQQFQY GEYGKLSEGD PKILERSKRL VSKINDFSQL
130 140 150 160 170 180
KILPEVRDKL MEVISSESLL NKNLLDVKYN PKENNVQEFK KHLKPSPIQT TAIYQTSKTL
190 200 210 220 230 240
MDPQLQVRLI AAETGSGKTM AYLIPLVDYL KRTEMENPSW ETLKDKAIVR SIILLPTHEL
250 260 270 280 290 300
VEQVYQTVSK LEPALGMHTY KWDAGSSYKG FVEALKGRID IMVTTPGKIL SLFNISMVNR
310 320 330 340 350 360
PDRILSQVKF LVMDEADTLL DKSWVEDSYS TIKHMQNLNH VLFCSATIPK EFQKTITRLF
370 380 390 400 410 420
PTVGVIASPN LHKINHKNQI KLINADMAPY KGSKTKALAQ ILYSINRDNI DPGFEKRVVI
430 440 450 460 470 480
FVNEKENVPL VATKLANQYG HDVVALTGND SVEERLEKIK PFMDPPKKMT TRKSEKVTTE
490 500 510 520 530 540
NTVTMKIPNS NIVIEEIPED NEAFVESTLK VLVTTDVLAR GINFRGCRYV VLYDIPNTPV
550 560 570 580
DLVHRVGRTG RMNQKGSVFI ITGKRVKNWV KAIPSIVSKN VSIS