Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q6CVE0

Entry ID Method Resolution Chain Position Source
AF-Q6CVE0-F1 Predicted AlphaFoldDB

No variants for Q6CVE0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6CVE0

No associated diseases with Q6CVE0

2 regional properties for Q6CVE0

Type Name Position InterPro Accession
domain B30.2/SPRY domain 158 - 345 IPR001870
domain SPRY domain 220 - 344 IPR003877

Functions

Description
EC Number
Subcellular Localization
  • Vacuole membrane ; Single-pass type II membrane protein
  • Endosome membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
endosome membrane The lipid bilayer surrounding an endosome.
fungal-type vacuole A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
vacuolar membrane The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway The process of directing proteins towards the vacuole that contributes to protein catabolism via the multivesicular body (MVB) pathway.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGLIVLQDGF PNDRPIQGFP SDPVVRVPDD TIPADDAFSL MFLISLSITF GLLLLVLILI
70 80 90 100 110 120
SIYLTFCGGN DGDDSDDEDE DGTSVSFKFF RKRNSLLLDS SFMTPGKFDD DESLKVREAK
130 140 150 160 170 180
ELPKMSSFEV ELYERTKEFQ KMSPPMVKPL GSFLNSQDKQ VIKDRGIQSY FFLPSINDNV
190 200 210 220 230 240
DINGAFLPSF FVEDKLNVSF TKFNISSSAI MNYPLPMNKK DAVYFEVKVY KFKTCSNSIF
250 260 270 280 290 300
SIGLMTCPYP YFRIPGTAAY SIAYESTGKL RINNAFGADT LLPKLEEGDV VGFGYRYSSG
310 320 330 340 350 360
TIFITHNGKK MMDVTHKVGI DLFVGLGAMN AAYTRTYTKD GLFEDPDNVS FRQKWSELQA
370 380 390 400 410 420
FNNGESSSDY IDARNVISKD LLQVHDPKED TVSSDNIELH VNLGQLGFVF IEANVKKYAF
430 440 450 460 470 480
GSVYGDIGIP PAYNGDDIKQ DMLLQKGDEL PPEYPDDAVD FFGDIHSPAS TSEPPSATFS
490 500 510 520 530 540
AGLPMDNAAD TPVSTADADA DADADADEEE PLISVKKPAA QTHSKKNNKK KKKKKSNRNR
RG