Q6CUD5
Gene name |
ATG12 (KLLA0C05720g) |
Protein name |
Ubiquitin-like protein ATG12 |
Names |
Autophagy-related protein 12 |
Species |
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) |
KEGG Pathway |
kla:KLLA0_C05720g |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6CUD5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6CUD5-F1 | Predicted | AlphaFoldDB |
No variants for Q6CUD5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6CUD5 | |||||
No associated diseases with Q6CUD5
No regional properties for Q6CUD5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q6CUD5 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| Atg12-Atg5-Atg16 complex | A protein complex required for the expansion of the autophagosomal membrane. In budding yeast, this complex consists of Atg12p, Atg5p and Atg16p. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| phagophore assembly site membrane | A cellular membrane associated with the phagophore assembly site. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| Atg8 ligase activity | Catalysis of the covalent attachment of the ubiquitin-like protein Atg8 to substrate molecules; phosphatidylethanolamine is a known substrate. |
| enzyme activator activity | Binds to and increases the activity of an enzyme. |
| protein tag | A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| autophagy of mitochondrion | The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions. |
| cytoplasm to vacuole transport by the Cvt pathway | A cytoplasm to vacuole targeting pathway that uses machinery common with autophagy. The Cvt vesicle is formed when the receptor protein, Atg19, binds to the complexes of the target protein (aminopeptidase or alpha-mannosidase homododecamers), forming the Cvt complex. Atg11 binds to Atg9 and transports the Cvt complex to the pre-autophagosome (PAS). The phagophore membrane expands around the Cvt complex (excluding bulk cytoplasm) forming the Cvt vesicle. This pathway is mostly observed in yeast. |
| late nucleophagy | A type of nucleophagy, distinct from piecemeal microautophagy of the nucleus (PNM) where the nuclear material is delivered to the vacuole/lysosome for breakdown and recycling later than observed for PNM. |
| piecemeal microautophagy of the nucleus | Degradation of a cell nucleus by lysosomal microautophagy. |
| protein lipidation involved in autophagosome assembly | The protein lipidation process by which phosphatidylethanolamine is conjugated to a protein of the ATG8 family, leading to membrane insertion of the protein as a step in autophagosome assembly. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNSGVLLSES | ETDTSEVSGR | QSELISGDES | IKGKLEEFSA | KLNELRLADG | NSDGGDEEES |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LSPDTKSQRE | ESSENSENVS | RSTSRPPLTS | SIVSSVEREQ | LKSQVKVKIR | LQPIGAIPQI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QPRVCQISAH | QQFLALTRFL | CKRLKRKHIH | CYINNAFAPS | LDQNIGDLWT | QFKVNDELIV |
| SYCETVAFG |