Q6CU02
Gene name |
ATG15 (KLLA0C08679g) |
Protein name |
Putative lipase ATG15 |
Names |
Autophagy-related protein 15 |
Species |
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) |
KEGG Pathway |
kla:KLLA0_C08679g |
EC number |
3.1.1.3: Carboxylic ester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6CU02
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6CU02-F1 | Predicted | AlphaFoldDB |
No variants for Q6CU02
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6CU02 | |||||
No associated diseases with Q6CU02
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.1.3 | Carboxylic ester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| multivesicular body membrane | The lipid bilayer surrounding a multivesicular body. |
| vacuolar lumen | The volume enclosed within the vacuolar membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| phospholipase activity | Catalysis of the hydrolysis of a glycerophospholipid. |
| triglyceride lipase activity | Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| multivesicular body membrane disassembly | The controlled breakdown of the membranes of multivesicular bodies. |
| neutral lipid catabolic process | The chemical reactions and pathways resulting in the breakdown of neutral lipids, lipids only soluble in solvents of very low polarity. |
| pexophagy | The selective autophagy process in which a peroxisome is degraded by macroautophagy. |
| phosphatidylserine catabolic process | The chemical reactions and pathways resulting in the breakdown of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. |
| piecemeal microautophagy of the nucleus | Degradation of a cell nucleus by lysosomal microautophagy. |
| vacuolar protein processing | Protein processing that takes place in the vacuole. Most protein processing in the vacuole represents proteolytic cleavage of precursors to form active enzymes. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKPGIKISKR | YSARNASVIT | VLLLLIYLIY | INKETIQTKY | QGSRINHDSG | GDSTKDKTHT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FTIKEIHFRP | LDEKTQSYGS | LQVTPEFVNM | AKSEFEQNVA | VASGDNEDLY | DKQLWSASIK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SNPWTHQFTL | KQGSIKMKRM | VNRDPDYVES | FLDYAHENPE | MARKVHLDWV | DESVLAPNVT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DKETVISLAL | MSSNAYVRLP | YEGDWRNLSD | WNNDLNPDLS | VGIGWDSDGV | RGHIFSNDDS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SVIVIALKGT | SAQGLPGSGE | DETTDNDKLN | DNVLFSCCCA | RVSYLWKTAC | DCYVKSYTCD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EKCLEQELVR | KDRYYQAVLD | IYRSVVTAHP | NSAIWITGHS | LGGALASLLG | RTFGAPAVAF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EAPGELLATK | RLHLPMPPGL | PAYQEGVWHI | GHTADPIFMG | TCNGASSSCS | IAGYAMETSC |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HSGKVCVYDV | VTDKGWHVNM | LNHRIHTVID | GILTDYDTVA | KCKTPDACHD | CFNWNYVKGR |
| 490 | 500 | 510 | 520 | 530 | |
| DVPKKHKSSS | STASSTSAET | STLTVGPSPP | EKTTTSCIGR | NWIGICTEYG | I |