Q6CTW6
Gene name |
COX10 (KLLA0C09548g) |
Protein name |
Protoheme IX farnesyltransferase, mitochondrial |
Names |
Heme O synthase |
Species |
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) |
KEGG Pathway |
kla:KLLA0_C09548g |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6CTW6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6CTW6-F1 | Predicted | AlphaFoldDB |
No variants for Q6CTW6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6CTW6 | |||||
No associated diseases with Q6CTW6
1 regional properties for Q6CTW6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | UbiA prenyltransferase conserved site | 192 - 214 | IPR030470 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrial membrane | Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| protoheme IX farnesyltransferase activity | Catalysis of the reaction: protoheme IX + (2E,6E)-farnesyl diphosphate + H2O = heme O + diphosphate. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| heme A biosynthetic process | The chemical reactions and pathways resulting in the formation of heme A, a derivative of heme found in cytochrome aa3. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSLVIQPLLM | RALNPNLSSI | LISGRGFSLI | QHRRFAFRAG | SGNNNSEQNQ | VHINTAPIEF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TANLLAGKNE | TEAETEGLKG | TALKALRCND | TTSDSEPQHN | MENLPFKVKL | VDKGQRKQIK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ESKARVEPRP | EVSLKKTYIE | PYLQLSKPRL | TVLVMLSAIC | SYALSPYPAT | VLQLLSLTVG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TTLCSASANA | INMGREPDFD | RQMIRTQARP | VVRGIVSPNQ | AFKFATAAGT | LGTSILWLGV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NPTVAFLGFS | NIALYAWLYT | SLKRKHIINT | WVGALVGAIP | PLMGWAASSP | LSHPGAWCLA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GLLYAWQFPH | FNTLSHNIRN | EYKNAGYVMT | AWKNPKLNAR | VALRYSLLMF | PLCFGLSYFN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VTDWYYQLDS | AFVNAWMSLW | AFKFYFQQKR | NYSKEIYNNK | TEFNKGLAMA | NVYARRTFWV |
| 430 | 440 | 450 | |||
| SVLHLPAVLI | LAILHKKDRW | DWLFEDKKQL | SA |