Q6CSW1

PR
Gene name
ROK1 (KLLA0C17424g)
Protein name
ATP-dependent RNA helicase ROK1
Names
Species
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
KEGG Pathway
kla:KLLA0_C17424g
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-153 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6CSW1

Entry ID Method Resolution Chain Position Source
AF-Q6CSW1-F1 Predicted AlphaFoldDB

No variants for Q6CSW1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6CSW1

No associated diseases with Q6CSW1

6 regional properties for Q6CSW1

Type Name Position InterPro Accession
conserved_site ATP-dependent RNA helicase DEAD-box, conserved site 289 - 297 IPR000629
domain Helicase, C-terminal 355 - 517 IPR001650
domain DEAD/DEAH box helicase domain 157 - 333 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 152 - 359 IPR014001
domain RNA helicase, DEAD-box type, Q motif 133 - 161 IPR014014
domain DDX52/Rok1, DEAD-box helicase domain 144 - 347 IPR044764

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
small-subunit processome A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

4 GO annotations of biological process

Name Definition
endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage within the 5'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. Endonucleolytic cleavage within the 5'-ETS of the pre-RNA is conserved as one of the early steps of rRNA processing in all eukaryotes, but the specific position of cleavage is variable.
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage between the 5'-External Transcribed Spacer (5'-ETS) and the 5' end of the SSU-rRNA of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA.
snoRNA localization Any process in which small nucleolar RNA is transported to, or maintained in, a specific location.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDIFRVLTRG ASIRKNGDSN RTQSADFSMA NEKKSKTAGS SSTPARDEQQ LTKELDFFRN
70 80 90 100 110 120
KKIMNKVKSE STKGEGEDEV QEDNQEEDED HADDETELSG KIITKQDALK LRKSYQGNVS
130 140 150 160 170 180
GNSVPLPIGS FEDLITRFQF DKRLLNNLIE NNFTEPTPIQ SESIPILLHE RDMIACAPTG
190 200 210 220 230 240
SGKTLAFLIP LLQQIINDKT TVGLKGLIIS PTKELANQIF IECSKLANKI YLDKKRPLQV
250 260 270 280 290 300
ALLSKSLSSK LKNKVISEDK YDIIISTPLR LITVVQEEAL NLGKVKHLIF DEADKLFDKT
310 320 330 340 350 360
FVEQTDDILS SCTDPHLRKT MFSATIPSNV EEIAQTIMND PIRVIIGHKE AANINIDQQL
370 380 390 400 410 420
VFCGNEEGKL IAIRQLVLEG EFKPPVIIFL ESITRAKALF HELLYDKLNV DVIHAERTQV
430 440 450 460 470 480
QRDKIIERFK SGDLWCLICT DVLARGVDFK GVNLVINYDV PRSAQAYVHR IGRTGRGGRS
490 500 510 520 530 540
GKAITFYTKQ DSLAIKPIIN VMKQSGCEVS EWMQKISSMS KREKESLKKG KGHVERKQIS
550 560 570
TVPKVVKQKK RQRREMIEAS KKRKLSVSDA EEEAGNDST