Q6CSB9
Gene name |
ARP4 (KLLA0D02288g) |
Protein name |
Actin-related protein 4 |
Names |
Actin-like protein ARP4, Actin-like protein 4 |
Species |
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) |
KEGG Pathway |
kla:KLLA0_D02288g |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6CSB9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6CSB9-F1 | Predicted | AlphaFoldDB |
No variants for Q6CSB9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6CSB9 | |||||
No associated diseases with Q6CSB9
1 regional properties for Q6CSB9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Heat shock protein 70, conserved site | 439 - 453 | IPR018181 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| Ino80 complex | A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity. |
| NuA4 histone acetyltransferase complex | A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60). |
| Swr1 complex | A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| histone acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone. |
| histone binding | Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| chromatin remodeling | A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. |
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| kinetochore assembly | The aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSNPALQVYG | GDEINAIVID | PGSFVTNIGY | SGTDCPQSIM | PSSYGNVETD | GDTKRIFNEQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PLLFPRAGME | IKPIVENSTI | VDWDRAQEQW | EYALNTDLKF | ESNKGTPVLL | TEPIWNSEAS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RKKSLEILLE | SMEFEACYLA | ANSSAVSFAM | GRPTCLVVDI | GHDVSTVSPV | IDGMTLSKSS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TRNYVAGKYL | NHLIAKNLKP | REIVPIFQVL | KKKPDFVKRT | LSFDVNESVI | NFANERQFFQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EFKETLLHIA | PKSLSSFKDE | LATQTKRSLE | APWGEELIFD | ADTRYSFAEQ | LFRPVKEDFP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EGWPASTDGI | VKTWHNDYVP | LKRTKPGTST | NTKEKENTAE | STPVPASTEQ | EAVDSPSQEP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NENGKRPVEN | KEDSSNNEQN | SNEIKNEDAN | SNESSAKATV | PSNGIQAKGE | DEVAGIVDLI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NKSMMEADVD | LRATLAHNVV | LTGGTSKIPG | LSDRIMHELN | KSLPALKFRM | LSSGHLRERQ |
| 490 | 500 | 510 | |||
| YQGWLGGSIL | ASLGTFHQLW | VGREEYEEVG | PERLLKDRFR |