Q6CS27

PR
Gene name
MCR1 (KLLA0D04488g)
Protein name
NADH-cytochrome b5 reductase 2
Names
Mitochondrial cytochrome b reductase
Species
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
KEGG Pathway
kla:KLLA0_D04488g
EC number
1.6.2.2: With a heme protein as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

66-143 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6CS27

Entry ID Method Resolution Chain Position Source
AF-Q6CS27-F1 Predicted AlphaFoldDB

No variants for Q6CS27

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6CS27

No associated diseases with Q6CS27

8 regional properties for Q6CS27

Type Name Position InterPro Accession
domain Oxidoreductase FAD/NAD(P)-binding 160 - 266 IPR001433
domain Flavoprotein pyridine nucleotide cytochrome reductase 100 - 107 IPR001709-1
domain Flavoprotein pyridine nucleotide cytochrome reductase 159 - 178 IPR001709-2
domain Flavoprotein pyridine nucleotide cytochrome reductase 185 - 194 IPR001709-3
domain Flavoprotein pyridine nucleotide cytochrome reductase 197 - 208 IPR001709-4
domain Flavoprotein pyridine nucleotide cytochrome reductase 253 - 261 IPR001709-5
domain Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain 52 - 150 IPR008333
domain FAD-binding domain, ferredoxin reductase-type 47 - 151 IPR017927

Functions

Description
EC Number 1.6.2.2 With a heme protein as acceptor
Subcellular Localization
  • Mitochondrion outer membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of mitochondrial outer membrane The component of the mitochondrial outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial intermembrane space The region between the inner and outer lipid bilayers of the mitochondrial envelope.

2 GO annotations of molecular function

Name Definition
cytochrome-b5 reductase activity, acting on NAD(P)H Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5).
NADH dehydrogenase activity Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor.

2 GO annotations of biological process

Name Definition
cellular response to oxidative stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
ergosterol biosynthetic process The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFARLSRSNK FLPIALGVGA ASIATAIILQ RNYSIMNDTS KAFLGDNEWI DLPIIKIEKL
70 80 90 100 110 120
SHDTKRFTFA LPKKDQVSGL ITASCILAKF VTPKGSNVIR PYTPVSDNGT KGKMELVVKH
130 140 150 160 170 180
YENGKFTSHL FGLKENDTVS FKGPITKWEW KPNSYDSITL LGAGTGINPL YQLVHHIAEN
190 200 210 220 230 240
PEDNTKIHLY YGNKTPEDIL LKSELDNLQK KYPDQVKITY FVDKAEGNFE GETGFITKDY
250 260 270 280 290
LSHQAPKPSE KNQVFVCGPP PFMKAYSGPK VSPQDQGELT GILAELGYSK SNVFKF