Q6CR51

PR
Gene name
SSN3 (CDK8, SRB10, KLLA0D11814g)
Protein name
Serine/threonine-protein kinase SSN3
Names
Cyclin-dependent kinase 8, KlSRB10
Species
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
KEGG Pathway
kla:KLLA0_D11814g
EC number
2.7.11.22: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-223 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

329-355 (Activation loop from InterPro)

Target domain

90-489 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q6CR51

Entry ID Method Resolution Chain Position Source
AF-Q6CR51-F1 Predicted AlphaFoldDB

No variants for Q6CR51

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6CR51

No associated diseases with Q6CR51

2 regional properties for Q6CR51

Type Name Position InterPro Accession
domain Protein kinase domain 90 - 489 IPR000719
active_site Serine/threonine-protein kinase, active site 308 - 320 IPR008271

Functions

Description
EC Number 2.7.11.22 Protein-serine/threonine kinases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
CKM complex Cyclin-dependent kinase complex which reversibly associates with the Mediator complex. In Saccharomyces cerevisiae it consists of SSN2, SSN3, SSN8 and SRB8.
mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
metal ion binding Binding to a metal ion.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
RNA polymerase II CTD heptapeptide repeat kinase activity Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II.

7 GO annotations of biological process

Name Definition
negative regulation of filamentous growth Any process that decreases the frequency, rate or extent of the process in which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
nuclear-transcribed mRNA catabolic process, non-stop decay The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that is lacking a stop codon.
phosphorylation of RNA polymerase II C-terminal domain The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex.
positive regulation of transcription from RNA polymerase II promoter by galactose Any process involving galactose that activates or increases the rate of transcription from an RNA polymerase II promoter.
protein destabilization Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.
response to oxidative stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MYGNQQNNSN PYQMSYYRMN NGQGQGTNRW PQQLSHQEML AGHSQQILNN NKPAGNQSKP
70 80 90 100 110 120
PIVMASNNVF SIGPYRQRKD SSRISVLQKY EIIGYIAAGT YGKVYKAKAR DYQNGMNRDN
130 140 150 160 170 180
VIILDSPDSV SADSNLDINS INRSTRQQEA NDNLTTMDFR KPSHKRFTPP NNSNSTQIRS
190 200 210 220 230 240
NSGSETNVRI NSSSITNNSR KPSQIQFYAI KKFKTEREGV EHYTGISQSA CREMSLCREL
250 260 270 280 290 300
DNNHLTKLVE IFLEKKSIYM VSEFAEHDLL QIIHFHSHPE KRLIPPRMLK SIMWQILDGV
310 320 330 340 350 360
SYLHQNWILH RDLKPANIMV TVDGCVKIGD LGLARKFNNM VQTLYTGDKV IVTIWYRAPE
370 380 390 400 410 420
LILGARHYTP AIDLWAVGCI FAELIGLRPI FKGEEAKMES KKSVLFQANQ FQKILEVMGS
430 440 450 460 470 480
PDHKIWPNID SYPEYLQLAK MPKYRDNLTA WYQTAGGKDK TALDILYRLL QYDPIKRIDA
490 500 510 520 530 540
IDALDHVYFT NGDPPVCENV FEGLNYKYPP RRIHTNDNDI TNVGNDNNQA NHSQKQPMHG
550 560 570 580 590
NNNNKNGNMN GLGVNKRILA AAAAAAAAAA VSGNGNNPTS NTATGGSARK KRK