Q6CQR6

PR
Gene name
MRD1 (KLLA0D14949g)
Protein name
Multiple RNA-binding domain-containing protein 1
Names
Species
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
KEGG Pathway
kla:KLLA0_D14949g
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

194-348 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6CQR6

Entry ID Method Resolution Chain Position Source
AF-Q6CQR6-F1 Predicted AlphaFoldDB

No variants for Q6CQR6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6CQR6

No associated diseases with Q6CQR6

6 regional properties for Q6CQR6

Type Name Position InterPro Accession
domain RNA recognition motif domain 2 - 90 IPR000504-1
domain RNA recognition motif domain 330 - 408 IPR000504-2
domain RNA recognition motif domain 516 - 588 IPR000504-3
domain RNA recognition motif domain 651 - 734 IPR000504-4
domain RNA recognition motif domain 752 - 829 IPR000504-5
domain Mrd1, RNA recognition motif 3 517 - 587 IPR034482

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
90S preribosome A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
small-subunit processome A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.

1 GO annotations of molecular function

Name Definition
rRNA primary transcript binding Binding to an unprocessed ribosomal RNA transcript.

4 GO annotations of biological process

Name Definition
endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage within the 5'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. Endonucleolytic cleavage within the 5'-ETS of the pre-RNA is conserved as one of the early steps of rRNA processing in all eukaryotes, but the specific position of cleavage is variable.
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage between the 5'-External Transcribed Spacer (5'-ETS) and the 5' end of the SSU-rRNA of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA.
small-subunit processome assembly The aggregation, arrangement and bonding together of proteins and RNA molecules to form a small-subunit processome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSRVIVKGLP IYLKEDRLRD LIEKRLTQKH QSTDVQSYLS DVKLMKNRDG ESRRFAFIGF
70 80 90 100 110 120
RDEEDAFDCV NYFNGTFVDT SKIEVSMAKS FADPRVPQPM REKRREALKR LREREELLLA
130 140 150 160 170 180
DKKDSQKKQK SDSNNDGGKK HDIDAEIAKN KQLQEFINTM KPSSQVTSWE TVQSSKTQGE
190 200 210 220 230 240
DEEAADDEVG EMSSNPLLSQ ALALKGNSRD ADEDTDMFKL PGNESDDEYV SLNGGSNNAN
250 260 270 280 290 300
TDEPEPQMMS LDTFDTAGPT STDDMAKDEA VSDLDWLKNR RVRIKDGADT PVSKQQQQPD
310 320 330 340 350 360
TEQQQPEETE VETSQESEEE KSLKKIRETG RLFLRNILYT ATEDDFRKLF SPYGELEEVH
370 380 390 400 410 420
IAVDTRTGQS KGFAYVLFKN ADNAATAFVE LDKQIFQGRL LHILPADAKK SHKLDEFDLK
430 440 450 460 470 480
NLPLKKQREL KRKANSAQQT FSWNSLYMNQ DAVLSSVADK LGMKKSELID AENSSSAVKQ
490 500 510 520 530 540
ALAEASVIGD VRKFFETRGV DLTKFAQLKN SERDDRVILV KNFPYGTTRE EIAELFLPFG
550 560 570 580 590 600
KLQRLLLPPS GTIAILQFRD VPAARAAFSK ISYKRFKDGI IYLEKGPSDC FTRDAQGDEL
610 620 630 640 650 660
VESETDIQKA TAKEAKISGA DLLEAQSLPA ADKDDHDDDD DDDDVQAGPT VSIFIKNLNF
670 680 690 700 710 720
STTSQQLTEK FKPFNGFVVA QVKTKPDPKQ PGKTLSMGFG FAEFKTKEQA NAVISAMEGT
730 740 750 760 770 780
ILDGHKLQLK LSHRQGTSTT NASSKKKKKN QGKIIVKNLP FEATRKDVFE LFSSFGQLKS
790 800 810 820 830 840
VRVPKKFDKS ARGFAFVEFL LPKEAENAMD QLQGVHLLGR RLVMEFVEQD PEDVEQQIEK
850 860 870
MTRKVKKQVN TTKIANMRNS GKRKIDLDED DENDGLQG