Q6CQJ9
Gene name |
SLX4 |
Protein name |
Structure-specific endonuclease subunit SLX4 |
Names |
|
Species |
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) |
KEGG Pathway |
kla:KLLA0_D16544g |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6CQJ9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6CQJ9-F1 | Predicted | AlphaFoldDB |
No variants for Q6CQJ9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6CQJ9 | |||||
No associated diseases with Q6CQJ9
No regional properties for Q6CQJ9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q6CQJ9 | |||
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| Slx1-Slx4 complex | A heterodimeric protein complex that possesses an endonuclease activity that specifically cleaves certain types of branched DNA structures; because such structures often form during the replication ribosomal DNA (rDNA) repeats, the complex plays a role in the maintenance of rDNA. The subunits are known as Slx1 and Slx 4 in budding and fission yeasts, and are conserved in eukaryotes. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| 5'-flap endonuclease activity | Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA recombination | Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. |
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| DNA replication | The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. |
| organelle organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MHDELEKAGR | HLLMVNDHLS | EDSVEQGDIC | MTQVPTMFSD | DEDQDEEQET | EIPPEEGDDD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ILISTQVQGA | IDELNHQETV | VHTFRNVLSR | FALETQDQAD | IPLVSSKKVP | VKKVIKSSKV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KQPTARLQKR | IKSITQFNTD | NWESNRVKDR | AQKMISILSG | KSAKVKKLVS | KLDSEASADA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ESLQDSHPTQ | FAPFNESEWQ | HIVGLLREKL | PKVSRSELNS | VQQYVYGADE | QHNLWKASQL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SPEKQISSQC | SDGESETILP | SLTLDNNAPV | YTLSQLVEGE | SSNNRCSTED | GLRFKPISNP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SSVIEQELPI | SIDVPSSETD | VPSQIADSCD | SGSIISFEEL | SFMIQDKNKA | DVDYDIPCYL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PPDSKTLPTG | EKTKREYSRA | NINDQLINIS | QTSYDVVSSI | VSPMKAQRTG | TIQVPATRTT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TFQDQQQQNQ | QQASKPANVV | KIYVDSNRDS | NDVFASVKGE | VDTQEQESLS | TLTTSMLHDD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NNEIVIDSED | ERGSYSIMEV | HDAPQTHLGQ | FPSLRKSQSQ | KLKTPVSATD | SLDSQLQPAL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LTTQNASPNT | AKLRRSFKVI | GLKPCKNKVQ | MLQVWETLES | KFPGSSDEDR | SIQLKQFLTD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LIVQNRDESA | LLMEQIYTFE | PIRYEQLKEW | LVSLNSFTEL | IDDSFIKNWA | DLNGIVFRND |
| 670 | 680 | 690 | |||
| TENPLLSQSQ | SQSQSRLLSQ | SLSQLQSPSL | SP |