Q6CPU0

PR
Gene name
DXO1
Protein name
Decapping and exoribonuclease protein 1
Names
KlDxo1, 5'-3' exoribonuclease Dxo1, NAD-capped RNA hydrolase Dxo1, DeNADding enzyme Dxo1
Species
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
KEGG Pathway
kla:KLLA0_E02245g
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-60 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q6CPU0

Entry ID Method Resolution Chain Position Source
4GPS X-ray 240 A A 1-403 PDB
4GPU X-ray 280 A A 1-403 PDB
AF-Q6CPU0-F1 Predicted AlphaFoldDB

No variants for Q6CPU0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6CPU0

No associated diseases with Q6CPU0

No regional properties for Q6CPU0

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q6CPU0

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
5'-3' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end.
metal ion binding Binding to a metal ion.
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA NAD-cap (NAD-forming) hydrolase activity Catalysis of the reaction: a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+).

3 GO annotations of biological process

Name Definition
NAD-cap decapping Cleavage of the 5'-NAD-cap of an RNA. The NAD-cap is present at the 5'-end of some RNAs in both bacetria and eukaryotes. While it promotes RNA stability in bacteria, it promotes RNA decay in eukaryotes.
nuclear mRNA surveillance A process that identifies and degrades defective or aberrant mRNAs within the nucleus.
nucleic acid phosphodiester bond hydrolysis The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTTVSCDKDE NKVDQLGESL SQLRISTRKN NKPSQKKGSL VLSCKKFPHV SVNYVVDKTP
70 80 90 100 110 120
KLLTDCKEVH NCSYIINDAT LLWNEASRKP RLRPEVCTYI KDSKWENKAV KDSFIGIDLT
130 140 150 160 170 180
KGYDDYVPLD RNVLNSLVIL KEAYQRYEKT LNPEKTTFVS LRHHIIDIIM CPFLDEPLSL
190 200 210 220 230 240
LMTVQPDKNI LISVDKSKDK PNGIHETRNS FNKKICYTGF ALEDLLIESP TEGHILEHEL
250 260 270 280 290 300
YYSIVHGSLN DEIDLLIQAE MDSINTLTDT YTEIKSSVHF KLGNTYHRRK LLRMWIQTNL
310 320 330 340 350 360
LPKSDLLIGF RNSYSNELEQ LKAYKIQDIY HKINNSSIVG KPGKFYKFNP NVANDWFQHI
370 380 390 400
FQVLKQNLLL LSQESTSTTF KVQIDTNLTL SISPASQFVT ALG