Q6CP23

PR
Gene name
PAN3
Protein name
PAN2-PAN3 deadenylation complex subunit PAN3
Names
PAB1P-dependent poly(A)-specific ribonuclease, Poly(A)-nuclease deadenylation complex subunit 3, PAN deadenylation complex subunit 3
Species
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
KEGG Pathway
kla:KLLA0_E08097g
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

11-236 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6CP23

Entry ID Method Resolution Chain Position Source
AF-Q6CP23-F1 Predicted AlphaFoldDB

No variants for Q6CP23

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6CP23

No associated diseases with Q6CP23

3 regional properties for Q6CP23

Type Name Position InterPro Accession
domain Zinc finger, CCCH-type 15 - 44 IPR000571
domain Protein kinase domain 296 - 656 IPR000719
domain Pan3 pseudokinase domain 517 - 654 IPR041332

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
PAN complex A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
poly(A) binding Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.

4 GO annotations of biological process

Name Definition
mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
nuclear-transcribed mRNA poly(A) tail shortening Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length.
postreplication repair The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication.
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MISSASGTNW NRPDSFKGTQ CRNIIIHGYC KFENEGCQFN HGNSKETEGQ TTDEVPTQRS
70 80 90 100 110 120
MTPLNVKFNA KTSSSFTPGK SPAVRSPDFS SLPAFQPGAP VNDQPMLADG PQISGTMSPS
130 140 150 160 170 180
LMNSNATAFA PSFNPYASES FTPSVSAGGI PSSQELAGTL HGSNPSIPSP VPSNPYVNSA
190 200 210 220 230 240
GLPSGGMLGV GHPMQGLPPP PPPGALPVNP ITQFPTVYPP THSVLQYHLY APDPPPHLKI
250 260 270 280 290 300
PLKPNERTPE TLFINNHLRD RLVKNNQTAL QVFPRGSLPD IVGDYFGLVP MDFHNRTSDK
310 320 330 340 350 360
KRYNGHKNSL YKVFSNLDGK IYFMRRIHDV KITDSAQVSK PFQTWSHLRS ANITVLKDSF
370 380 390 400 410 420
VTSAFNDSSL CMVFDYYPQS QSLYETYGLA NSVNELNQEY LWAFLVQLTI ALQEVHSNGL
430 440 450 460 470 480
ALNDLDWKKV IVTGEPGRIK VTDIGVYDTL NYHQEGRMLH TEQQQNYLSL AELLLNLVQR
490 500 510 520 530 540
LCGASGPLDD VKSYHIDPLF KKCIQYLQDT SNNNKNIEDF TKLFSHKVLS VVNSLQYNSE
550 560 570 580 590 600
YLEQQLSREL ENARLFRLMC KLNAIYGRLE SRIDINWAES GEKFPIILFF DYVFHQKDDT
610 620 630 640 650
GKNVMDLTHV LRCLNKLDAG VSERLMLVTP DEMNCIIISY KELKDLIDST FRALTQ