Q6CP20

PR
Gene name
SSN8 (KLLA0E08151g)
Protein name
RNA polymerase II holoenzyme cyclin-like subunit
Names
Species
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
KEGG Pathway
kla:KLLA0_E08163g
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-91 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6CP20

Entry ID Method Resolution Chain Position Source
AF-Q6CP20-F1 Predicted AlphaFoldDB

No variants for Q6CP20

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6CP20

No associated diseases with Q6CP20

3 regional properties for Q6CP20

Type Name Position InterPro Accession
domain Cyclin, N-terminal 66 - 173 IPR006671
domain Cyclin-like domain 78 - 167 IPR013763-1
domain Cyclin-like domain 183 - 274 IPR013763-2

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
CKM complex Cyclin-dependent kinase complex which reversibly associates with the Mediator complex. In Saccharomyces cerevisiae it consists of SSN2, SSN3, SSN8 and SRB8.
mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.

2 GO annotations of molecular function

Name Definition
cyclin-dependent protein serine/threonine kinase regulator activity Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins.
RNA polymerase II core promoter sequence-specific DNA binding Binding to a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene.

4 GO annotations of biological process

Name Definition
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
positive regulation of transcription by galactose Any process involving galactose that activates or increases the rate of transcription.
positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle.
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSASYWDSSQ RHKWKYTRES LAKEKQKLWL LECQLFPQGL NVTIHDSKAN KQVTTNIPVT
70 80 90 100 110 120
QRDLHYDRDY NLRIYCYFLI MKLGRRLNIR QCALVTAHVY LSRFLLRASV REVNLYLLIT
130 140 150 160 170 180
TCIYLACKVE ECPQHIRTLV NEARSLWPEF IPPDVTKVTE FEFYLIEELQ SYLIVHHPYR
190 200 210 220 230 240
SLEQIEKALS SEKYNYKLSD DELQKIWSLI NDSYTTDVHL LYSPHVIAIS CLFAVSCIIH
250 260 270 280 290 300
KPEDSTKRAN INMFIAETQV NLEQVMFILQ ELISLYDHWD KYNELRIRAL LHELYLRQQT
PAIQ