Q6CNC2

PR
Gene name
NOP9 (KLLA0E13685g)
Protein name
Nucleolar protein 9
Names
Pumilio domain-containing protein NOP9
Species
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
KEGG Pathway
kla:KLLA0_E13685g
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-271 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6CNC2

Entry ID Method Resolution Chain Position Source
AF-Q6CNC2-F1 Predicted AlphaFoldDB

No variants for Q6CNC2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6CNC2

No associated diseases with Q6CNC2

8 regional properties for Q6CNC2

Type Name Position InterPro Accession
repeat Pumilio RNA-binding repeat 90 - 125 IPR001313-1
repeat Pumilio RNA-binding repeat 126 - 162 IPR001313-2
repeat Pumilio RNA-binding repeat 185 - 220 IPR001313-3
repeat Pumilio RNA-binding repeat 287 - 322 IPR001313-4
repeat Pumilio RNA-binding repeat 335 - 370 IPR001313-5
repeat Pumilio RNA-binding repeat 372 - 408 IPR001313-6
repeat Pumilio RNA-binding repeat 513 - 550 IPR001313-7
repeat Pumilio RNA-binding repeat 551 - 588 IPR001313-8

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
90S preribosome A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
preribosome, small subunit precursor A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit.
small-subunit processome A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.

1 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.

4 GO annotations of biological process

Name Definition
endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage within the 5'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. Endonucleolytic cleavage within the 5'-ETS of the pre-RNA is conserved as one of the early steps of rRNA processing in all eukaryotes, but the specific position of cleavage is variable.
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage between the 5'-External Transcribed Spacer (5'-ETS) and the 5' end of the SSU-rRNA of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA.
ribosomal small subunit export from nucleus The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MARVRGRKLI KKLKKDEFHP EDNKTHDEPT VSHVNETAGG DNSDVSPNTF FGVLDSGELD
70 80 90 100 110 120
YFKKAESTLA IDTFENPDEK YQFINSVIEE SKGKELKLAT SQISSKLMER IIMESDETQL
130 140 150 160 170 180
KTIFKAFNGF YFNLACHKYS SHVLETLLVR GAAQVEKELL TPDFDSVDEG EFVTTESLFL
190 200 210 220 230 240
FLTNELQPNL RFMVSHQYAS HVLRILILVL SSKTLPSTVQ NNSTLRSKKS KIARKMIDIK
250 260 270 280 290 300
DNDNYNKIFK TPDSFKVVLR SMLSSIYTSF THGIPQGSGH FSEISLADVM KFREICVDKI
310 320 330 340 350 360
GSPVIQLVIQ VEGIFDRDRS YWHLIFKDSD EKDPKEESFV EYLLSDAVGS HFLQNVIAST
370 380 390 400 410 420
RIKYVERLYR LYMKDRIPKL AKRDTTAAFV LQSLLKVLNS KEVKEIMDEL VPDLSVLLNS
430 440 450 460 470 480
NMDFGTEIID ASIRHDNYLR DEIIEQLMKK YYPRESSDKN ILESCLQLSS STLGNTRDDW
490 500 510 520 530 540
PTAEERRKSL FLEKLIDYDD CFLNSTIDSM LNLPAERLLQ MPYHGVFSHV VEHVLQVKRV
550 560 570 580 590 600
AIIKRKLLLN VLCKDIVNLS CNAYGSHIVD KLWTFTAKLA MYKERIATAL CADSEKVKNS
610 620 630 640 650 660
VYGRQVWKNW SLELFVRKRY DWKKIVKEQE LEMFPDSKPL QPKTFKRPNN NNNSDVSPSF
KKSKFQKK