Q6CN53
Gene name |
TRM61 (KLLA0E15290g) |
Protein name |
tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 |
Names |
tRNA(m1A58)-methyltransferase subunit TRM61, tRNA(m1A58)MTase subunit TRM61 |
Species |
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) |
KEGG Pathway |
kla:KLLA0_E15225g |
EC number |
2.1.1.220: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6CN53
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6CN53-F1 | Predicted | AlphaFoldDB |
No variants for Q6CN53
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6CN53 | |||||
No associated diseases with Q6CN53
No regional properties for Q6CN53
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q6CN53 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.220 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| tRNA (m1A) methyltransferase complex | A protein complex involved in the catalysis of the formation of the modified nucleotide 1-methyladenosine (m1A) in tRNA. In yeast, it is a heterotetramer of two subunits, Gcd10p and Gcd14p, while in bacteria and archaea it is a homotetramer. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| tRNA (adenine-N1-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSQFFEYKDT | IKEGDLVLAW | LSRDNLKPIT | VKAGEVFNTR | YGAFSHSDMI | GKPFGSQIAI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RTKGSNRFGF | IHVLQPTPEL | WSISLPHRTQ | IVYTPDSSYI | MQRMECNPRS | RVIEAGTGSG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SFSHAFARSA | GHLFSYEFHE | VRYEQAKQEF | KEHGLLEAGN | TTITHRDVCK | DGFEIKNGDT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TSHEFRGPEE | TKVELNADCI | FLDLPAPWDA | IPNLTSVISK | EKKVNLCCFS | PCIEQVDKTL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EALEEEGWQD | VQTVEIQGRQ | YEARRQMVRR | LDDAIERLRD | VKRRKHEGVE | KRQKNVEQTS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NNGSSVEATE | SDKDLKHTEK | THFNPFGKGS | RVKEGDSNFE | WTQVSKVELE | IKSHTSFLTF |
| 370 | 380 | 390 | 400 | ||
| ASKIIDRTRD | EEQTKAYLAT | FKDEGSKLSK | REQRRLKAQA | NKDIQKE |