Q6CMN5
Gene name |
PAN2 |
Protein name |
PAN2-PAN3 deadenylation complex catalytic subunit PAN2 |
Names |
PAB1P-dependent poly(A)-specific ribonuclease, Poly(A)-nuclease deadenylation complex subunit 2, PAN deadenylation complex subunit 2 |
Species |
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) |
KEGG Pathway |
kla:KLLA0_E18877g |
EC number |
3.1.13.4: Exoribonucleases producing 5'-phosphomonoesters |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6CMN5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6CMN5-F1 | Predicted | AlphaFoldDB |
No variants for Q6CMN5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6CMN5 | |||||
No associated diseases with Q6CMN5
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.13.4 | Exoribonucleases producing 5'-phosphomonoesters |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| PAN complex | A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| nucleic acid binding | Binding to a nucleic acid. |
| poly(A)-specific ribonuclease activity | Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA processing | Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. |
| nuclear-transcribed mRNA poly(A) tail shortening | Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length. |
| postreplication repair | The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNNWQLSYQS | PEDLTYHLKK | PYLQYDKKEK | QVTKVVFDTE | ANLIWAGDSY | GRVSSYDPTY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SLYTRHTAHI | GSMPVVDLLS | NKNGILSLSS | DSLHFSNRRG | VTQMSLTSAD | IAQLSDMKTM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CYYTNNQNQV | LCAGGNTASG | IISVDLIKGT | LASSTYFTSK | VKHMSSNNKL | VAIGKQAGSI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DLFDPVSNRV | IHSLSGHSAS | ITSMDFKDNT | LVTAGKSKTF | GYLQSDQFIN | VYDVRIMKQL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PPISFSKTPN | FVGNHTSSKF | PIGADFLQLH | PVLPTVVAVA | SSSGSFDFID | LVNPSLRTPY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IHPCKSISQF | TLSPSGDYLA | FLEEESMINM | WNRSNSMSGF | TNSAAVLEYQ | DYPEDSFIPY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RVEVGQESYP | LSSIGLPYYS | ETLLSAWPHT | VFKTEGIISK | KIEGSSSSET | DNNSTKSVNR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SLSHLSSSKY | SLQPYNKFKY | GPRNVIEPYK | SLRERRKKMV | STTEDNQHRK | ELLEYKPSNN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IDIPPAYSKL | QMIYGKFGVM | DFDFGGFNTT | QYSGLETDID | CVYINEIIHL | YRFVPEVYNF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VVNCLEDEHI | QEKSVLTELG | FLFDMMTRAN | GKICRASNFV | DVLESISTAN | ELGLFTDEIS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TVSGHAGKPS | LDEGNLSSHI | YNLNLSVDAD | AEEIMKRSYG | KYMTVAQKFN | IFLLDRLISE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| EVERKLHSTD | AIVLEELFGL | NVDTEIHTLS | TCGNFVRQPH | LVSSLVVLSP | ASNNVKYSNK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| KLSNQTILPY | IESSMCRFKQ | LTARCSKCEK | LQNQEYESIV | RNLPPLLSLN | ICLSPEEWTT |
| 790 | 800 | 810 | 820 | 830 | 840 |
| AKTVNGWLSN | HFFATISKDR | PILKLQATDL | KTSNAIFKYE | LMSYVARITD | DFGEEHLVTY |
| 850 | 860 | 870 | 880 | 890 | 900 |
| AKILDQKIQQ | YKWYMFNDFL | VQEIDEDEAL | NISYWWKTPE | IVVYSDAEEI | RKPFVSVSKL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| KVDTDILYRD | YFSEGIRKDV | IRQYRLLTKD | EAPGPGTLVA | LDAEFVSLTE | PYLEINCKGM |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| KTLLKPAKKS | LARVSLLRGE | GELEGVPFID | DYIINECHIE | DYLTQFSGIE | PGDLDPKLSK |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| KSLVKRQVFY | RKMWLLLQLG | CVFVGHGLTN | DFRQINIYVP | ESQIRDTSLY | YLKGKRYLSL |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| RYLAFAVLRK | QVQTGNHDSI | EDAHTALLLY | RKYLELKEKG | VFEMYLENIY | DEGRKFGFKV |
| PDTI |