Q6CMG6
Gene name |
UBC6 (KLLA0E20493g) |
Protein name |
Ubiquitin-conjugating enzyme E2 6 |
Names |
E2 ubiquitin-conjugating enzyme 6, Ubiquitin carrier protein UBC6, Ubiquitin-protein ligase UBC6 |
Species |
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) |
KEGG Pathway |
kla:KLLA0_E20395g |
EC number |
2.3.2.23: Aminoacyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6CMG6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6CMG6-F1 | Predicted | AlphaFoldDB |
No variants for Q6CMG6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6CMG6 | |||||
No associated diseases with Q6CMG6
1 regional properties for Q6CMG6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Ubiquitin-conjugating enzyme E2 | 5 - 154 | IPR000608 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.2.23 | Aminoacyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ubiquitin conjugating enzyme activity | Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y -> Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| protein monoubiquitination | Addition of a single ubiquitin group to a protein. |
| protein polyubiquitination | Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain. |
| ubiquitin-dependent ERAD pathway | The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASIQANKRL | TKEYKNIVNN | PPPFIIAAPH | EDNILEWHYV | ITGPPSTPYE | NGQYHGTLTF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PSDYPFNPPA | IRMITPNGRF | KENTRLCLSM | SDYHPEAWNP | AWSVVTILNG | LLSFMTGDEQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TTGSVSTSDK | DKRTLAKKSK | HFNTYSNFKF | KNMFPDLRES | NIKDIEREAA | LEAESKGAQQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EENKAQKLAT | EKATSLDDIS | DPEDRVRIQE | LIKAEKDKKD | QDKNPGENSN | IKSLLCLILA |
| 250 | |||||
| IAIFFVGLIM | K |