Q6CLQ5

PR
Gene name
SHM1 (KLLA0F01210g)
Protein name
Serine hydroxymethyltransferase, mitochondrial
Names
SHMT, Glycine hydroxymethyltransferase, Serine methylase
Species
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
KEGG Pathway
kla:KLLA0_F01210g
EC number
2.1.2.1: Hydroxymethyl-, formyl- and related transferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-61 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6CLQ5

Entry ID Method Resolution Chain Position Source
AF-Q6CLQ5-F1 Predicted AlphaFoldDB

No variants for Q6CLQ5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6CLQ5

No associated diseases with Q6CLQ5

2 regional properties for Q6CLQ5

Type Name Position InterPro Accession
binding_site Serine hydroxymethyltransferase, pyridoxal phosphate binding site 265 - 281 IPR019798
domain Serine hydroxymethyltransferase-like domain 42 - 440 IPR039429

Functions

Description
EC Number 2.1.2.1 Hydroxymethyl-, formyl- and related transferases
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
glycine hydroxymethyltransferase activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

2 GO annotations of biological process

Name Definition
glycine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of glycine from other compounds, including serine.
tetrahydrofolate interconversion The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLSRSARCSR AVLFSAKRSL ASQANTGANA SANQVMVSKH VQDIDPEMYD ILTKERKRQK
70 80 90 100 110 120
HSITLIPSEN FTSKSVMDLL GSEMQNKYSE GYPGERYYGG NQFIDMAESL CQKRALELYN
130 140 150 160 170 180
LDPQLWGVNV QPLSGAPANL YAYSAVMETN DRLMGLDLPH GGHLSHGYQL PSGTKISYIS
190 200 210 220 230 240
KYFQTMPYHV DSQTGIIDYD FLSKTSKLFR PKVIVAGASA YSRVLDYKRF KEIADACGAY
250 260 270 280 290 300
LMSDMAHISG LVAAGVTRSP FEYSDIVTTT THKSLRGPRG AMIFYRKGVR KVTKKGKEVL
310 320 330 340 350 360
YDLDKRINFS VFPGHQGGPH NHTISALAVA LKQAATPEFK EYQAAVVENA RIFGEELVKK
370 380 390 400 410 420
GFELVSGGTD THLILINLSN LGIDGARLET LLENINIAAN KNTIPGDKSA LFPSGLRVGT
430 440 450 460 470 480
PAMTTRGFGP QEFAQVAAYI DRAVKLAIGI KSQESPDAKD ARSKLASFKE LCKESDQVKQ
490
LADEVYQWVG EFPVPGEL