Q6CLC8

PR
Gene name
COG6 (KLLA0F03993g)
Protein name
Conserved oligomeric Golgi complex subunit 6
Names
COG complex subunit 6, Component of oligomeric Golgi complex 6
Species
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
KEGG Pathway
kla:KLLA0_F03993g
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

31-124 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6CLC8

Entry ID Method Resolution Chain Position Source
AF-Q6CLC8-F1 Predicted AlphaFoldDB

No variants for Q6CLC8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6CLC8

No associated diseases with Q6CLC8

No regional properties for Q6CLC8

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q6CLC8

Functions

Description
EC Number
Subcellular Localization
  • Golgi apparatus membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
Golgi transport complex A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name Definition
cytoplasm to vacuole transport by the Cvt pathway A cytoplasm to vacuole targeting pathway that uses machinery common with autophagy. The Cvt vesicle is formed when the receptor protein, Atg19, binds to the complexes of the target protein (aminopeptidase or alpha-mannosidase homododecamers), forming the Cvt complex. Atg11 binds to Atg9 and transports the Cvt complex to the pre-autophagosome (PAS). The phagophore membrane expands around the Cvt complex (excluding bulk cytoplasm) forming the Cvt vesicle. This pathway is mostly observed in yeast.
intra-Golgi vesicle-mediated transport The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDFLDFPALV VDESAALPQP ASRLSLASLR LNDDEQEAKF VLPNVSKHDT EFTDLHSKMK
70 80 90 100 110 120
HFASISLGEI RPASVSLSKE VAAPISNNIE KPTTTNQLLS KKINSLLNVP NYASYTSDSE
130 140 150 160 170 180
TKRALQILDA NHSDLGLNFN QLVASDFVGT LNRKSLRSKL ENSMLNSHSD ILSNFQSIAR
190 200 210 220 230 240
RIKRLSGPLE RINNAMQNFK DTTESIDFEF EHVKDRLDQL KARRQVIIKL RDSLTLTQLE
250 260 270 280 290 300
LDHLQNGTIN DLFFQILNKI NFIKEKATYL LSNEKTTSAG VALLKTMNNN LTVSNKRIYN
310 320 330 340 350 360
YLINFIEEYD TLSRQYGERT IGDESLSNFQ TSLIHLSNDV QFFQDFLNRI VGLRSKRLLD
370 380 390 400 410 420
DFLSQFDIDN KKLQRPIILS AHDPVRYLGD VLAYVHSMIV NELEFLKSTF KLKSELVTSD
430 440 450 460 470 480
SVLKDNMDFI GDLHLKLLNE IFTSLANTIR IRLEQIVRFE NNPMLNLDIV QCLSLYQMML
490 500 510 520 530 540
VKNGINESSQ LMTSLNDLEN LARSKIVSSV TSYLKDLDKN QIAAADLLPP DWFVDYLSKL
550 560 570 580 590 600
SQLLNKLEQQ NETRILTDDL YDKLILDPIN NNLVLNLQNW FPTAKKEKSA RIDLLIVQIN
610 620 630 640 650 660
SFDLVKSKLG PFHSTIFSSD YGKSVFSKLE TQYTLCVTKL KETMNSYLFE STGMELYFNL
670 680 690 700 710 720
FNMIFPIISV QDELDYDMYL SAVENPIMKL AVIHDNIHEK LNTYLPLAVS DFQDVKLFNL
730 740 750 760 770
MPPAVEEDIV STCFGNFIKF YKVFKSVLNK IYPEDEEMIM STLNFTTNEV STLLGVEDK