Q6CKI5

PR
Gene name
ERT1 (KLLA0F10417g)
Protein name
Transcription activator of gluconeogenesis ERT1
Names
Species
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
KEGG Pathway
kla:KLLA0_F10417g
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

19-329 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6CKI5

Entry ID Method Resolution Chain Position Source
AF-Q6CKI5-F1 Predicted AlphaFoldDB

No variants for Q6CKI5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6CKI5

No associated diseases with Q6CKI5

3 regional properties for Q6CKI5

Type Name Position InterPro Accession
domain PAS domain 379 - 498 IPR000014
domain Zn(2)Cys(6) fungal-type DNA-binding domain 7 - 52 IPR001138
domain PAS fold 382 - 498 IPR013767

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
DNA-binding transcription repressor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
zinc ion binding Binding to a zinc ion (Zn).

3 GO annotations of biological process

Name Definition
gluconeogenesis The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
negative regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source A transcription regulation process in which the presence of a nonfermentable carbon source leads to a decrease of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources.
positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source A transcription regulation process in which the presence of a nonfermentable carbon source leads to an increase of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSVKRNKKVS VACVHCAKSH VTCDDNRPCT RCIRKGLEES CIDAPRKKVK YLRDVPEDQL
70 80 90 100 110 120
PSVLRSTKQV PPVNAVKLKM EPGILPNIPL DYDGGTIRQS APANNGKNNP ETQQTLSNGQ
130 140 150 160 170 180
ITHRPKFLSS AADLEYSILS DIIHGDSLFN KIPVNFLYSN PTEKTPSPIN QGSLNGQQDL
190 200 210 220 230 240
HFSLQLRSKP MNQIRGNTRA IYSNLLGPVS HEILQSEFNL YTNHFPLQPQ ESLDGTLDFK
250 260 270 280 290 300
RMTIGTLSPH LTKFDKTINQ YYLNFANTFP EIYDSRKIPN LSYALEVEPP EYREIPHDTE
310 320 330 340 350 360
IPHTLRFTTP SEIYSLVQTA FPSTTGFHAL LRYLKRRFDK NQLVEMCRCL AELRPIFIAS
370 380 390 400 410 420
TIDLTDEDMI FMEKSHQRTL LEYEKFISQV GTPTCVWRRN GQISYVNDEF SLLTGWNRLE
430 440 450 460 470 480
LLNKMTFIVE LMDGDTVMEY FQTFTRVAYQ GFRGAETMRI CNLLTPIKGS VIKCCCLWTL
490 500
KRDAFGLPMM IIGNFMPILT LPEDVGF