Q6CKI1

PR
Gene name
PRP5 (KLLA0F10505g)
Protein name
Pre-mRNA-processing ATP-dependent RNA helicase PRP5
Names
Species
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
KEGG Pathway
kla:KLLA0_F10505g
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

654-725 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6CKI1

Entry ID Method Resolution Chain Position Source
AF-Q6CKI1-F1 Predicted AlphaFoldDB

No variants for Q6CKI1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6CKI1

No associated diseases with Q6CKI1

5 regional properties for Q6CKI1

Type Name Position InterPro Accession
conserved_site ATP-dependent RNA helicase DEAD-box, conserved site 402 - 410 IPR000629
domain Helicase, C-terminal 481 - 639 IPR001650
domain DEAD/DEAH box helicase domain 270 - 443 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 265 - 471 IPR014001
domain RNA helicase, DEAD-box type, Q motif 245 - 274 IPR014014

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
nucleic acid binding Binding to a nucleic acid.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

1 GO annotations of biological process

Name Definition
mRNA branch site recognition Recognition of the pre-mRNA branch site sequence by components of the assembling spliceosome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDQTEKLRIR QEKLAKWKKQ KLNNDVTASV SVDAKEERLK KLEAWKKKKK QQDELKQKDI
70 80 90 100 110 120
KLTSIKSADR DRNKRRGQCS RKRPAFGGSD SESDDENSTS TLFKPRRNDT NTHVLTKDNS
130 140 150 160 170 180
KDDLDDGNDA LDEYIHKLID KDSNTNRVRL IDNISEDEDA NDSSSEKTIS QEEAPVDSEI
190 200 210 220 230 240
LFKKKGRKKI KAIDYSKVLN LITLNKCLYR EPNDLGLMSE KDVEELRLSL DNIKISGKDC
250 260 270 280 290 300
PKPVTKWSQL GLSSEIMDLI SNELQFVTLT PIQCQAIPAI MSGRDVIGIS KTGSGKTVAF
310 320 330 340 350 360
LLPLVRQIKA QPPLAPDETG PIGLILTPTR ELAVQIQEEA LKFCKGSGIS SICCVGGSEL
370 380 390 400 410 420
KQQINELKRG VDIIVATPGR FIDLMTLNSG HLLSPTRISF VVMDEADRLF DLGFGPQVNQ
430 440 450 460 470 480
IMGCIRPDKQ CVLFSATFPS KLKHFASRTL KNPIQITINS KSLINENIQQ RVQIFDEEHV
490 500 510 520 530 540
KFEFLLKRLS DRLALHRGED EKTIIFVGSQ QLCDLLYDEL LLNGITTFPI HAGKPSAERL
550 560 570 580 590 600
RNLQKFKETD NGILICTEVL SRGLNVPEVS LVIIYNAAKT IAQYVHTVGR TGRGTNNGVA
610 620 630 640 650 660
LSFVMVDELA SAYILVKCMK ENELSSVPMV VYQKLKEMND EFSSGLKTGK YRLIQGFGGK
670 680 690 700 710 720
GLDHLDELNE AKQSQEYTDY GVVENEEDVT EEESGATKME YTRGKREEGH STTYFAHINI
730 740 750 760 770 780
NDLPQLARWE ATKTETVSNI KQETGCNFES KGSFYPEGKG PKNDTDDPKL YLIVEGAEES
790 800 810
DVTMALELLN TKVKEGIRKA AVKDIQSGKY RM