Q6CKF0

PR
Gene name
RRD2 (KLLA0F11187g)
Protein name
Serine/threonine-protein phosphatase 2A activator 2
Names
Peptidyl-prolyl cis-trans isomerase PTPA-2, PPIase PTPA-2, Rotamase PTPA-2, Phosphotyrosyl phosphatase activator 2
Species
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
KEGG Pathway
kla:KLLA0_F11187g
EC number
5.2.1.8: Cis-trans isomerases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

281-350 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6CKF0

Entry ID Method Resolution Chain Position Source
AF-Q6CKF0-F1 Predicted AlphaFoldDB

No variants for Q6CKF0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6CKF0

No associated diseases with Q6CKF0

No regional properties for Q6CKF0

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q6CKF0

Functions

Description
EC Number 5.2.1.8 Cis-trans isomerases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit.

3 GO annotations of molecular function

Name Definition
peptidyl-prolyl cis-trans isomerase activity Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
phosphatase activator activity Binds to and increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule.
protein phosphatase regulator activity Binds to and modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule.

2 GO annotations of biological process

Name Definition
mitotic spindle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
response to osmotic stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAIKRLINEH DMELWNNSKT FEDVIGFINT LALSVRGREN NDYTQPISDN VQRVSNLLSK
70 80 90 100 110 120
VTEIIGKHEV IKDANTSRFG KIEFRDFYDD ISEHSNELIS KIFEGIEKPD TGKLDDICTY
130 140 150 160 170 180
FINSWGDRSR IDYGSGHELN FICFLYCLTE SKVFDLENDS SNIVLMLFIK YLGIMRSLEL
190 200 210 220 230 240
KYWLEPAGSH GVWGLDDYHF LPFLFGAFQL STHKHLKPKS IHNPEVVEMF QDRYLYFGCI
250 260 270 280 290 300
AFINKVKTTA SLRWHSPMLD DISGVKRWSK VAEGMVKMYK AEVLQKLPIM QHFYFGYFLK
310 320 330 340 350
CPEGVSEPSA RAQDHHEDDS CCTDGSHGHS TWADCCGIAV PSAIAASQMA NKDVRLFPFD