Q6CJV1

PR
Gene name
DRS1 (KLLA0F15752g)
Protein name
ATP-dependent RNA helicase DRS1
Names
Species
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
KEGG Pathway
kla:KLLA0_F15752g
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

3-80 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6CJV1

Entry ID Method Resolution Chain Position Source
AF-Q6CJV1-F1 Predicted AlphaFoldDB

No variants for Q6CJV1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6CJV1

No associated diseases with Q6CJV1

5 regional properties for Q6CJV1

Type Name Position InterPro Accession
conserved_site ATP-dependent RNA helicase DEAD-box, conserved site 385 - 393 IPR000629
domain Helicase, C-terminal 465 - 628 IPR001650
domain DEAD/DEAH box helicase domain 258 - 428 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 252 - 454 IPR014001
domain RNA helicase, DEAD-box type, Q motif 233 - 261 IPR014014

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
preribosome, large subunit precursor A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

2 GO annotations of biological process

Name Definition
ribosomal large subunit assembly The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit.
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAVKKFRSFD DFVPTISDSE EDVPDLDASD DEMEKKPVKS SKTKNKSKKK AKQQQGSHLD
70 80 90 100 110 120
EDVHEDLNPE FQFSIDSGEV TTNFAGWDFQ GDEKSDEVEK KDVDLDGIIR RKGGLIMMAA
130 140 150 160 170 180
TGSDAEESLS EESEEEPEEG DEPGESDDED ELALDGFGMG VKRKATEENE EDEEDEEEED
190 200 210 220 230 240
DDEDDDKKTE MSQADLGKGK DEDEDIEEDT KEEMAEFYAP EEESADAKKI VHKTFNSLSL
250 260 270 280 290 300
SRPVLKGLGS LGYTSPSPIQ SAAIPIALLG KDIIAGAVTG SGKTAAFMIP IIERLLYKPA
310 320 330 340 350 360
HIASTRVVVL TPTRELAIQV ADVGKNIGKF VNGLTFGLAV GGLNLRQQEQ ALKTRPDIVI
370 380 390 400 410 420
ATPGRFIDHL RNSASFSVDS VEILVIDEAD RMLEEGFQEE LQEIMSLIPS KRQTLLFSAT
430 440 450 460 470 480
MNSKIKQLIS LSLKKPVRIM IDPPKQAADK LTQEFIRIRK RDHLKPALLY QLIRKLDNTS
490 500 510 520 530 540
QKRIVVFVAR KETAHKLRIV LGLLGMQVGE LHGSLTQEQR LQSVNNFKSL QVPVLICTDL
550 560 570 580 590 600
ASRGLDIPKI EVVINFDMPK TYEIYLHRVG RTARAGREGR SVTFVGESSQ DRSIVRSAIR
610 620 630 640 650 660
SVEENAESGK ALSRNVDWTQ VEQVNSLIGA KGDVVEEIIE EEKQEKEILR AEMELRKGEN
670 680 690 700 710 720
MLKHKEEISA RPRRTWFQSE AEKKNSKMLQ VLAKNKKPIN SKKRKQQEAL AENPRLYKKT
730 740
QKDRVEYQER QYSKKQAAYG KKGKKGKK